公开(公告)号：EP2821504A1

公开(公告)日：2015-01-07

申请号：EP13755605.6

申请日：2013-02-28

申请人： National University Corporation Tokyo University of Agriculture and Technology ,  Tokyo Metropolitan University

发明人： TAKAHASHI, Nobuhiro ,  IZUMIKAWA, Keiichi ,  ISHIKAWA, Hideaki ,  YOSHIKAWA, Harunori ,  ISOBE, Toshiaki ,  TAOKA, Masato ,  NAKAYAMA, Hiroshi

IPC分类号： C12Q1/68 ,  A61K31/7088 ,  A61P21/04 ,  A61P25/16 ,  A61P25/28 ,  C40B30/06 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  G01N33/68 ,  C12N15/09

CPC分类号： G01N33/6845 ,  A61K31/7088 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/5038 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2333/4727 ,  G01N2333/90616 ,  G01N2500/04 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/2835

摘要： The present invention aims to develop and provide a method for identifying a disease associated with the abundance of TDP-43 in cells and a method for producing a TDP-43 binding inhibitor. By measuring the abundance of a measurement substance, the amount of binding between a measurement substance and TDP-43, etc. in cells obtained from a subject, it is identified whether or not the subject is suffering from a disease associated with the abundance of TDP-43 in cells. Also, a drug which can significantly reduce the binding between a measurement substance and TDP-43 is produced by adding a drug candidate substance.

摘要翻译： 本发明旨在开发和提供一种用于鉴定与细胞中TDP-43丰度相关的疾病的方法和用于产生TDP-43结合抑制剂的方法。 通过测量测量物质的丰度，从受试者获得的细胞中测量物质和TDP-43等之间的结合量，确定受试者是否患有与TDP丰度相关的疾病 -43细胞。 而且，通过添加药物候选物质，能够显着降低测定物质与TDP-43的结合的药物。