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公开(公告)号：EP1513923B1
公开(公告)日：2007-07-18
申请号：EP03731489.5
申请日：2003-05-30
申请人： NatureWorks LLC
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Kluyveromyces cells, methods for making the Kluyveromyces cells, and their use in production of organic products, particularly D-lactic acid.
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2.发明公开LACTIC ACID-PRODUCING YEAST CELLS HAVING NONFUNCTIONAL L-OR D-LACTATE: FERRICYTOCHROME C OXIDOREDUCTASE GENE 有权乳酸生产具有非功能性或L的D- LACTAT酵母细胞：高铁-C氧化还原酶基因：
公开(公告)号：EP1960516A2
公开(公告)日：2008-08-27
申请号：EP06850558.5
申请日：2006-11-17
申请人： NatureWorks LLC
发明人： MILLER, Matthew , SUOMINEN, Pirkko , ARISTIDOU, Aristos , HAUSE, Benjamin, Matthew , VAN HOEK, Pim , DUNDON, Catherine, Asleson
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D- lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
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3.发明公开GENETICALLY MODIFIED YEAST OF THE SPECIES ISSATCHENKIA ORIENTALIS AND CLOSELY RELATED SPECIES AND FERMENTATION PROCESSES USING SAME 审中-公开属东方伊萨酵母和密切相关的物种和发酵方法的基因修饰酵母SO
公开(公告)号：EP1885842A2
公开(公告)日：2008-02-13
申请号：EP06836073.4
申请日：2006-05-30
申请人： NatureWorks LLC
发明人： SUOMINEN, Pirkko , ARISTIDOU, Aristos , PENTTILA, Merja , ILMEN, Marja , RUOHONEN, Laura , KOIVURANTA, Kari , ROBERT-PEREZ, Kevin
CPC分类号： C12P7/56 , C12N9/0006
摘要： Cells of the species Issatchenkia orientalis and closely related yeast species are transformed with a vector to introduce an exogenous lactate dehydrogenase gene. The cells produce lactic acid efficiently and are resistant at low pH, high lactate titer conditions.
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4.发明公开GENETICALLY MODIFIED YEAST SPECIES AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权基因修饰，其中遗传修饰的酵母是所使用的酵母种类和发酵过程
公开(公告)号：EP1626979A2
公开(公告)日：2006-02-22
申请号：EP04751126.6
申请日：2004-05-03
申请人： NatureWorks LLC
发明人： RAJGARHIA, Vineet , KOIVURANTA, Kari , PENTTILÄ, Merja , ILMEN, Marja , SUOMINEN, Pirkko , ARISTIDOU, Aristos , MILLER, Chris , OLSON, Stacey , RUOHONEN, Laura
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
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