公开(公告)号：EP2898900A1

公开(公告)日：2015-07-29

申请号：EP14200659.2

申请日：2009-09-17

申请人： Nektar Therapeutics

发明人： Bossard, Mary J. ,  Roczniak, Steven O. ,  Zappe, Harold ,  Wang, Yujun ,  Zhang, Ping ,  Sheng, Dawei ,  Jude-Fishburn, C. Simone ,  Minamitani, Elizabeth ,  Moskowitz, Haim ,  Fry, Dennis ,  Ali, Cherie ,  Brew, Christine Taylor ,  Liu, Xiaofeng

IPC分类号： A61K47/48

CPC分类号： A61K47/48215 ,  A61K38/10 ,  A61K38/16 ,  A61K38/28 ,  A61K47/60 ,  A61K47/61

摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。

公开(公告)号：EP2898900B1

公开(公告)日：2017-11-15

申请号：EP14200659.2

申请日：2009-09-17

申请人： Nektar Therapeutics

发明人： Bossard, Mary J. ,  Roczniak, Steven O. ,  Zappe, Harold ,  Wang, Yujun ,  Zhang, Ping ,  Sheng, Dawei ,  Jude-Fishburn, C. Simone ,  Minamitani, Elizabeth ,  Moskowitz, Haim ,  Fry, Dennis G. ,  Ali, Cherie ,  Brew, Christine Taylor ,  Liu, Xiaofeng

IPC分类号： A61K47/60

CPC分类号： A61K47/48215 ,  A61K38/10 ,  A61K38/16 ,  A61K38/28 ,  A61K47/60 ,  A61K47/61

摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.