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    BIOMARKERS FOR EPICARDIAL ADIPOSE TISSUE
    3.
    发明公开
    BIOMARKERS FOR EPICARDIAL ADIPOSE TISSUE 审中-公开
    BIOMARKERFÜREPIKARDIALES FETTGEWEBE

    公开(公告)号：EP3092498A1

    公开(公告)日：2016-11-16

    申请号：EP14809047.5

    申请日：2014-12-09

    申请人： Nestec S.A.

    发明人： BEGUELIN, Fiona Camille ,  COLLINO, Sebastiano ,  MARTIN, François-Pierre ,  MONTOLIU ROURA, Ivan ,  SCHERER, Max

    IPC分类号： G01N33/92

    CPC分类号： G01N33/92 ,  A23L33/30 ,  A23V2002/00 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2570/00 ,  G01N2800/324 ,  G01N2800/50 ,  G09B19/00 ,  G09B19/0092

    摘要： A method for predicting the level of epicardial adipose tissue (EAT) in a subject comprising: (a) determining a level of one or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from the following: (i) phosphatidylcholine (PC) [16:1/16:1] (ii) diacylglycerol (DAG) [42:8] (iii) phosphatidylethanolamine-ether (PE-O) [32:5] (iv) phosphatidylcholine (PC) [18:0/22:5] (v) phosphatidylinositol (PI) [18:0/16:1] (vi) phosphatidylglycerol (PG) [20:3/20:3] (vii) phosphatidylglycerol (PG) [22:5/18:1] (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of levels of EAT fat in the subject.

    摘要翻译： 一种用于预测受试者的心外膜脂肪组织（EAT）水平的方法，包括：（a）测定来自受试者的样品中一种或多种脂质生物标志物的水平，其中所述生物标志物选自以下：（i）磷脂酰胆碱 （PC）[16：1/16：1]（ii）二酰基甘油（DAG）[42:8]（iii）磷脂酰乙醇胺 - 醚（PE-O）[32：5]（iv）磷脂酰胆碱（PC） （v）磷脂酰肌醇（PI）[18：0/16：1]（vi）磷脂酰甘油（PG）[20：3/20：3]（vii）磷脂酰甘油（PG）[22：5 / 18：1]（b）将样品中生物标志物的水平与参考值进行比较; 其中与参考值相比，样品中生物标志物的水平指示受试者中EAT脂肪的水平。

    EARLY BIOMARKERS OF AGE-RELATED LOW-GRADE INFLAMMATION
    9.
    发明公开
    EARLY BIOMARKERS OF AGE-RELATED LOW-GRADE INFLAMMATION 审中-公开
    与年龄有关的低档点火早期生物标记物

    公开(公告)号：EP2831594A1

    公开(公告)日：2015-02-04

    申请号：EP13708828.2

    申请日：2013-03-12

    申请人： Nestec S.A. ,  INRA

    发明人： BRAHMBHATT, Viral ,  BREUILLE, Denis ,  GUY, Philippe Alexandre ,  MONTOLIU ROURA, Ivan ,  PAPET, Isabelle ,  VIDAL, Karine

    IPC分类号： G01N33/68

    CPC分类号： G01N33/492 ,  G01N33/6893 ,  G01N2800/7042 ,  G01N2800/7095

    摘要： The present invention relates to a method for predicting the risk of acquiring an age-related low-grade inflammation for a subject, said method comprising a) providing a biological sample from a subject, b) determining in said sample the level of at least one biomarker selected from the group consisting of a compound of molecular weight between 859-863 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 861-86 g/mol and which is a diacylphosphatidylcholine, a compound of molecular weight between 791-794 g/mol and which is an alkylacylphosphatidylcholine, a compound of molecular weight between 522-525 g/mol and which is a monoacylphosphatidylcholine, octadecanoylcarnitine (C18), and tryptophan, c) comparing the level of the at least one biomarker to a reference level, and d) determining whether said subject is likely to be at risk of acquiring an age-related low-grade inflammation, when the level of biomarker(s) deviate significantly from the respective reference level.