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    CANCER
    2.
    发明公开
    CANCER 审中-公开

    公开(公告)号：EP3407977A2

    公开(公告)日：2018-12-05

    申请号：EP17703216.6

    申请日：2017-01-30

    申请人： Neuro-Bio Ltd

    发明人： GREENFIELD, Susan ,  TU, Henry ,  MORRILL, Paul ,  GARCIA-RATES, Sara ,  PEPPER, Chris ,  FEGAN, Chris

    IPC分类号： A61P35/00 ,  C12Q1/68 ,  C12N9/18

    CPC分类号： C12Q1/6886 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C12N9/18 ,  C12Q2600/106 ,  C12Y301/01007

    摘要： An inhibitor of the synthesis and/or activity of the T14 peptide (SEQ ID NO: 3, AEFHRWSSYMVHWK) derived from the C-terminus of tailed acetylcholinesterase (T-AchE) is disclosed for use in treating, ameliorating or preventing cancer or metastatic disease. Methods of screening a candidate agent to test whether or not the compound has efficacy for treating, preventing or ameliorating cancer or metastatic disease are also disclosed as are methods of screening a compound to test whether or not the compound causes cancer. SEQ ID NO: 3 is disclosed in diagnostic methods as a biomarker or prognostic indicator for cancer or metastatic disease. Preferably, the inhibitor inhibits the interaction or translocation of the T14 peptide with/to an allosteric site on alpha-7 nicotinic receptors (cholinergic receptor nicotinic alpha 7, NACHRA7, CHRNA7-2). Preferably, the cancer is leukaemia, lymphocytic leukaemia, chronic lymphocytic leukaemia (CLL), myeloid leukaemia, acute myeloid leukaemia (AML), multiple myeloma, breast cancer or plasmacytoma.