公开(公告)号：EP1090105A1

公开(公告)日：2001-04-11

申请号：EP99933396.6

申请日：1999-06-24

申请人： Neuronova AB

发明人： JANSON, Ann, Marie ,  FRISEN, Jonas ,  JOHANSSON, Clas ,  MOMMA, Stefan ,  CLARKE, Diana ,  ZHAO, Ming ,  LENDAHL, Urban ,  DELFANI, Kioumars

IPC分类号： C12N5/06 ,  A61K35/30

CPC分类号： C12N5/0623 ,  A61K35/12

摘要： The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.

公开(公告)号：EP1443955B1

公开(公告)日：2012-09-12

申请号：EP02798797.3

申请日：2002-09-19

申请人： Neuronova AB

发明人： DELFANI, Kioumars ,  JANSON, Ann, Marie ,  KUHN, Georg, H. ,  PLATE, Karlheinz ,  SCHANZER, Anne ,  WACHS, Frank-Peter ,  ZHAO, Ming

IPC分类号： A61P25/16 ,  A61K38/18

CPC分类号： A61K38/1858 ,  A61K35/30 ,  A61K38/179 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  G01N33/5008 ,  G01N2333/49 ,  G01N2333/515 ,  A61K2300/00

公开(公告)号：EP1090105B1

公开(公告)日：2005-04-13

申请号：EP99933396.6

申请日：1999-06-24

申请人： Neuronova AB

发明人： JANSON, Ann, Marie ,  FRISEN, Jonas ,  JOHANSSON, Clas ,  MOMMA, Stefan ,  CLARKE, Diana ,  ZHAO, Ming ,  LENDAHL, Urban ,  DELFANI, Kioumars

IPC分类号： C12N5/06 ,  A61K35/30

CPC分类号： C12N5/0623 ,  A61K35/12

摘要： The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.

公开(公告)号：EP1443955A1

公开(公告)日：2004-08-11

申请号：EP02798797.3

申请日：2002-09-19

申请人： Neuronova AB

发明人： DELFANI, Kioumars ,  JANSON, Ann, Marie ,  KUHN, Georg, H. ,  PLATE, Karlheinz ,  SCHANZER, Anne ,  WACHS, Frank-Peter ,  ZHAO, Ming

IPC分类号： A61K38/18 ,  A61K48/00 ,  A61P25/00

CPC分类号： A61K38/1858 ,  A61K35/30 ,  A61K38/179 ,  A61K38/1866 ,  A61K45/06 ,  A61K48/00 ,  G01N33/5008 ,  G01N2333/49 ,  G01N2333/515 ,  A61K2300/00

摘要： The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder. The reagent used is platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), a combination of both, a PDGF agonist or a VEGF agonist.