公开(公告)号：EP1919465A2

公开(公告)日：2008-05-14

申请号：EP06776492.8

申请日：2006-07-28

申请人： Neuropharma S.A.

发明人： MARTÍNEZ GIL, Ana ,  MEDINA PADILLA, Miguel ,  ALONSO CASCÓN, Mercedes ,  FUERTES HUERTA, Ana ,  NAVARRO RICO, María Luisa ,  PÉREZ PUERTO, María José ,  CASTRO MORERA, Ana ,  MARTÍN APARICIO, Ester

IPC分类号： A61K31/17 ,  A61K31/36 ,  A61P25/28 ,  A61P3/10 ,  A61P25/24

CPC分类号： C07D317/66 ,  A61K31/17 ,  A61K31/36

摘要： The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthasc kinase 3², GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus.

摘要翻译： 本发明涉及式（I）的脲衍生物作为糖原合成酶激酶3 2，GSK-3的抑制剂，制备这些化合物的方法，包含它们的药物组合物及其用于治疗和/或预防疾病的用途 其中涉及GSK-3，例如阿尔茨海默病或非胰岛素依赖性糖尿病。