公开(公告)号：EP1558255B1

公开(公告)日：2006-12-27

申请号：EP03751019.5

申请日：2003-10-07

申请人： Neuropharma, S.A.

发明人： MARTINEZ GIL, Ana ,  DORRONSORO DIAZ, Isabel ,  RUBIO ARRIETA, Laura ,  ALONSO GORDILLO, Diana ,  FUERTES HUERTA, Ana ,  MORALES-ALCELAY, Susana ,  DEL MONTE MILLAN, Maria ,  GARCIA PALOMERO, Esther ,  USAN EGEA, Paola ,  DE AUSTRIA, Celia ,  MEDINA PADILLA, Miguel

IPC分类号： A61K31/473 ,  C07D219/12 ,  C07D401/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  C07D219/12 ,  C07D417/12

摘要： A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer’s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.

公开(公告)号：EP1558255A2

公开(公告)日：2005-08-03

申请号：EP03751019.5

申请日：2003-10-07

申请人： Neuropharma, S.A.

发明人： MARTINEZ GIL, Ana ,  DORRONSORO DIAZ, Isabel ,  RUBIO ARRIETA, Laura ,  ALONSO GORDILLO, Diana ,  FUERTES HUERTA, Ana ,  MORALES-ALCELAY, Susana ,  DEL MONTE MILLAN, Maria ,  GARCIA PALOMERO, Esther ,  USAN EGEA, Paola ,  DE AUSTRIA, Celia ,  MEDINA PADILLA, Miguel

IPC分类号： A61K31/473 ,  C07D219/12 ,  C07D401/12 ,  C07D417/12

CPC分类号： C07D401/12 ,  C07D219/12 ,  C07D417/12

摘要： A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer’s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.

公开(公告)号：EP1689730A1

公开(公告)日：2006-08-16

申请号：EP04819730.5

申请日：2004-12-02

申请人： Neuropharma, S.A.

发明人： ALONSO GORDILLO, Diana ,  DORRONSORO DÍAZ, Isabel ,  MARTINEZ GIL, Ana ,  PANIZO DEL PLIEGO, Gema ,  FUERTES HUERTA, Ana ,  PÉREZ PUERTO, Ma José ,  MARTÍN APARICIO, Ester ,  PÉREZ NAVARRO, Darío ,  MEDINA PADILLA, Miguel

IPC分类号： C07D307/60 ,  C07D307/62 ,  A61K31/365 ,  A61P25/00 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D407/06

摘要： The present invention provides the use of a compound of formula (I); wherein: n is 0, 1, 2, or 3, the bonds shown with the dashed lines are saturated, or unsaturated with one or more double bonds; R, and R’ are independently selected from hydrogen, alkyl, aryl, -OH, -OR’’ -SH, -SR’’- NH’’ -NHR', =O, =NH, =NR'; R' is independently selected frorn alkyl, aryl, in the preparation of a medicament for the treatment of a disease requiring a GSK-3 inhibitor. Also provided is a compound of formula (II); wherein n is 0, 1, 2, or 3 the bonds shown with the dashed lines are saturated, or unsaturated with one or more double bonds. Also provided are methods of treating chronic neurodegenerative conditions.

公开(公告)号：EP1919465A2

公开(公告)日：2008-05-14

申请号：EP06776492.8

申请日：2006-07-28

申请人： Neuropharma S.A.

发明人： MARTÍNEZ GIL, Ana ,  MEDINA PADILLA, Miguel ,  ALONSO CASCÓN, Mercedes ,  FUERTES HUERTA, Ana ,  NAVARRO RICO, María Luisa ,  PÉREZ PUERTO, María José ,  CASTRO MORERA, Ana ,  MARTÍN APARICIO, Ester

IPC分类号： A61K31/17 ,  A61K31/36 ,  A61P25/28 ,  A61P3/10 ,  A61P25/24

CPC分类号： C07D317/66 ,  A61K31/17 ,  A61K31/36

摘要： The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthasc kinase 3², GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus.

摘要翻译： 本发明涉及式（I）的脲衍生物作为糖原合成酶激酶3 2，GSK-3的抑制剂，制备这些化合物的方法，包含它们的药物组合物及其用于治疗和/或预防疾病的用途 其中涉及GSK-3，例如阿尔茨海默病或非胰岛素依赖性糖尿病。