公开(公告)号：EP4375274A1

公开(公告)日：2024-05-29

申请号：EP22845935.0

申请日：2022-07-20

申请人： Nico Therapeutics, Inc.

发明人： INAGAKI, Yusuke ,  WASHIO, Takuya ,  KOIZUMI, Yuka ,  TOYA, Hiroki ,  YAMASHITA, Yumi ,  KURIWAKI, Ikumi ,  MAEDA, Junko ,  KOIKE, Takanori ,  KAMIKUBO, Takashi ,  YAMAKI, Susumu ,  KURAMOTO, Kazuyuki ,  SABA, Kengo ,  TOMIYAMA, Hiroshi ,  IWAI, Yoshinori ,  NAKAMURA, Akihiko

IPC分类号： C07D237/32 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/504 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07D237/26 ,  C07D237/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  C07D491/107 ,  C07D495/04

CPC分类号： A61K31/502 ,  A61K31/5025 ,  A61K31/504 ,  A61P25/28 ,  A61P25/00 ,  A61P29/00 ,  A61P37/02 ,  C07D237/26 ,  C07D237/32 ,  C07D237/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  C07D491/107 ,  C07D495/04

摘要： An object of the present invention is to provide a pharmaceutical composition, in particular, a compound suitable for preventing and/or treating inflammatory diseases and/or neurodegenerative disease. The present inventors have conducted intensive studies to find a compound having an inhibitory effect on NLRP3 inflammasome activation and found that an annulated pyridazine compound has an inhibitory effect on NLRP3 inflammasome activation, thus completing the present invention. The annulated pyridazine compound of the present invention is expected to serve as a prophylactic and/or therapeutic agent for inflammatory diseases and/or neurodegenerative diseases.