公开(公告)号：EP4375274A1

公开(公告)日：2024-05-29

申请号：EP22845935.0

申请日：2022-07-20

申请人： Nico Therapeutics, Inc.

发明人： INAGAKI, Yusuke ,  WASHIO, Takuya ,  KOIZUMI, Yuka ,  TOYA, Hiroki ,  YAMASHITA, Yumi ,  KURIWAKI, Ikumi ,  MAEDA, Junko ,  KOIKE, Takanori ,  KAMIKUBO, Takashi ,  YAMAKI, Susumu ,  KURAMOTO, Kazuyuki ,  SABA, Kengo ,  TOMIYAMA, Hiroshi ,  IWAI, Yoshinori ,  NAKAMURA, Akihiko

IPC分类号： C07D237/32 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/504 ,  A61P25/00 ,  A61P25/28 ,  A61P29/00 ,  A61P37/02 ,  C07D237/26 ,  C07D237/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  C07D491/107 ,  C07D495/04

CPC分类号： A61K31/502 ,  A61K31/5025 ,  A61K31/504 ,  A61P25/28 ,  A61P25/00 ,  A61P29/00 ,  A61P37/02 ,  C07D237/26 ,  C07D237/32 ,  C07D237/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/044 ,  C07D491/052 ,  C07D491/107 ,  C07D495/04

摘要： An object of the present invention is to provide a pharmaceutical composition, in particular, a compound suitable for preventing and/or treating inflammatory diseases and/or neurodegenerative disease. The present inventors have conducted intensive studies to find a compound having an inhibitory effect on NLRP3 inflammasome activation and found that an annulated pyridazine compound has an inhibitory effect on NLRP3 inflammasome activation, thus completing the present invention. The annulated pyridazine compound of the present invention is expected to serve as a prophylactic and/or therapeutic agent for inflammatory diseases and/or neurodegenerative diseases.

公开(公告)号：EP3256468A4

公开(公告)日：2018-07-25

申请号：EP16748725

申请日：2016-02-05

申请人： SUNSHINE LAKE PHARMA CO LTD

发明人： WANG XIAOJUN ,  YANG XINYE ,  PAN SHENGQIANG ,  GUO RUI ,  WU JUNWEN ,  ZHANG YINGJUN ,  CHENG CHANGCHUNG

IPC分类号： C07D413/12 ,  A61K31/42 ,  A61K31/4353 ,  A61K31/4985 ,  A61K31/519 ,  C07D249/06 ,  C07D261/08 ,  C07D411/12 ,  C07D471/04 ,  C07D491/044 ,  C07D491/052 ,  C07D491/147 ,  C07D497/04 ,  C07D498/04 ,  C07D498/14

CPC分类号： C07D261/08 ,  A61K31/42 ,  A61K31/4353 ,  A61K31/4985 ,  A61K31/519 ,  C07D249/06 ,  C07D411/12 ,  C07D413/12 ,  C07D471/04 ,  C07D491/044 ,  C07D491/052 ,  C07D491/147 ,  C07D497/04 ,  C07D498/04 ,  C07D498/14

摘要： The present invention relates to novel tricyclic compounds which can bind to FXR and act as modulators of the FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the uses of the compounds for the treatment of diseases and/or conditions mediated by FXR. The invention further provides a pharmaceutical composition containing the compound disclosed herein and a method of treatment of diseases and/or conditions mediated by FXR comprising administering the compound or the pharmaceutical composition.

公开(公告)号：EP2964645B1

公开(公告)日：2018-07-11

申请号：EP14760212.2

申请日：2014-03-08

申请人： ScinoPharm Taiwan, Ltd.

发明人： HENSCHKE, Julian P. ,  CHEN, Yue ,  HSIAO, Tsung, Yu

IPC分类号： C07D417/06 ,  C07D491/044 ,  C07D285/14

CPC分类号： C07D491/044

摘要： The present invention relates to a novel process of making ixabepilone, ixabepilone derivatives and analogues, and intermediates thereof.

公开(公告)号：EP3239142A1

公开(公告)日：2017-11-01

申请号：EP15873198.4

申请日：2015-12-24

申请人： Takeda Pharmaceutical Company Limited

发明人： SASAKI, Minoru ,  KIKUCHI, Fumiaki ,  IKEDA, Zenichi ,  KAKEGAWA, Keiko ,  NISHIKAWA, Yoichi ,  SASAKI, Shigekazu ,  FUKUDA, Koichiro ,  TAKAMI, Kazuaki ,  BANNO, Yoshihiro ,  KAMAURA, Masahiro

IPC分类号： C07D313/00 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/662 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07D313/20 ,  C07D321/00 ,  C07D321/12 ,  C07D323/00 ,  C07D405/06 ,  C07D409/12 ,  C07D491/044 ,  C07D493/04 ,  C07D495/04 ,  C07F9/655

CPC分类号： C07D495/04 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/662 ,  C07D313/00 ,  C07D313/20 ,  C07D321/00 ,  C07D321/12 ,  C07D323/00 ,  C07D405/06 ,  C07D409/12 ,  C07D413/06 ,  C07D491/044 ,  C07D493/04 ,  C07F9/655

摘要： The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].

摘要翻译： 本发明涉及具有肠肽酶抑制作用，可用于肥胖症，糖尿病等的治疗或预防的缩合杂环化合物及含有其的药物。 具体而言，本发明涉及由下式（I）表示的化合物或其盐，以及含有其的药物[式中，各符号如说明书中所定义]。

公开(公告)号：EP2750678B1

公开(公告)日：2017-03-22

申请号：EP12826819.0

申请日：2012-08-29

申请人： PTC Therapeutics, Inc.

发明人： BRANSTROM, Arthur ,  JOSYULA, Vara Prasad, Venkata Nagendra ,  ARNOLD, Michael, Andrew ,  GERASYUTO, Aleksey, I. ,  KARP, Gary ,  WANG, Jiashi ,  CHEN, Guangming ,  GINZBURG, Olya ,  HUANG, Song ,  PEDDI, Srinivasa ,  WOLL, Matthew,G. ,  SMITH, Sean Wesley ,  ZHANG, Xiaoyan ,  ZHANG, Nanjing ,  TURPOFF, Antony Allan ,  NARASIMHAN, Jana

IPC分类号： A61K31/473 ,  C07D221/14 ,  C07D221/16 ,  C07D471/04 ,  C07D491/04 ,  C07D471/14 ,  C07D495/04

CPC分类号： C07D491/052 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/437 ,  A61K31/438 ,  A61K31/473 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D221/10 ,  C07D221/14 ,  C07D221/16 ,  C07D401/04 ,  C07D471/04 ,  C07D471/14 ,  C07D491/044 ,  C07D491/048 ,  C07D491/14 ,  C07D495/04 ,  C07D519/00 ,  Y02A50/473 ,  Y02A50/475 ,  Y02P20/582 ,  A61K2300/00

摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

摘要翻译： 本说明书涉及其化合物及其形式及其药物组合物及其用于治疗或改善由野生型和多药耐药革兰氏阴性和革兰氏阳性病原体引起的细菌感染的方法。

公开(公告)号：EP2641907B1

公开(公告)日：2015-01-28

申请号：EP13161013.1

申请日：2010-05-20

申请人： AbbVie Inc. ,  AbbVie Deutschland GmbH & Co KG

发明人： Welch, Dennie, S. ,  Akritopoulou-Zanze, Irini ,  Braje, Wilfried ,  Djuric, Stevan, W. ,  Wilson, Noel, S. ,  Turner, Sean, C. ,  Kruger, Albert, W. ,  Relo, Ana-Lucia ,  Shekar, Shashank ,  Zhao, Hongyu ,  Gandarilla, Jorge ,  Gasiecki, Alan, F. ,  Li, Huanqiu ,  Thompson, Christina, M. ,  Zhang, Min

IPC分类号： C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61P25/00 ,  A61K31/551 ,  A61K31/554 ,  A61K31/553

CPC分类号： C07D513/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D495/04 ,  C07D495/16

摘要： The present application relates to processes for making aryl- and heteroaryl-fused decahydropyrroloazepine derivatives of formula (1-5), wherein the variables are as defined in the specification.

公开(公告)号：EP2736337A4

公开(公告)日：2014-12-17

申请号：EP12817789

申请日：2012-07-26

申请人： CHDI FOUNDATION INC

发明人： DOMINIGUEZ CELIA ,  TOLEDO-SHERMAN LETICIA M ,  COURTNEY STEPHEN MARTIN ,  PRIME MICHAEL ,  BROWN CHRISTOPHER JOHN ,  DE AGUIAR PENA PAULA C ,  JOHNSON PETER

IPC分类号： A01N43/54 ,  C07D239/42 ,  C07D471/04

CPC分类号： A61K31/506 ,  A61K31/505 ,  A61K31/513 ,  A61K31/5377 ,  C07D239/26 ,  C07D239/28 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052

公开(公告)号：EP2731950A1

公开(公告)日：2014-05-21

申请号：EP12738589.6

申请日：2012-07-13

申请人： AstraZeneca AB

发明人： JOHANSSON, Lars, Anders, Mikael

IPC分类号： C07D491/044 ,  C07D491/048 ,  A61K31/397 ,  A61K31/407 ,  A61P3/04

CPC分类号： C07D491/107 ,  C07D491/044 ,  C07D491/048

摘要： Disclosed herein are azetidinyl compounds of formula I, as described herein, pharmaceutical compositions comprising an azetidinyl compound, and a method of using an azetidinyl compound in the treatment or prophylaxis of a melanin- concentrating hormone related disease or condition.

公开(公告)号：EP2710010A1

公开(公告)日：2014-03-26

申请号：EP12721519.2

申请日：2012-05-15

申请人： Sandoz AG

发明人： BLATTER, Fritz ,  REICHENBÄCHER, Katharina

IPC分类号： C07D491/044 ,  A61K31/407 ,  A61P25/18

CPC分类号： C07D491/22 ,  A61K31/407 ,  C07D491/044

摘要： The present invention relates to novel crystalline salts of Asenapine and to methods of their preparation. In particular, the invention relates to crystalline Asenapine salts of tartaric acid or succinic acid, wherein the salts are e.g. selected from the group consisting of Asenapine D, L-tartrate hydrate form A, Asenapine D, L-tartrate hydrate form B, Asenapine D, L-tartrate anhydrous form, Asenapine succinate form X, Asenapine succinate form, and Asenapine succinate form II. Furthermore the present invention relates to pharmaceutical compositions comprising the novel salts and to the novel salts for use in the treatment of psychotic diseases or disorders.

公开(公告)号：EP2710009A1

公开(公告)日：2014-03-26

申请号：EP12720511.0

申请日：2012-05-15

申请人： Sandoz AG

发明人： BLATTER, Fritz ,  REICHENBÄCHER, Katharina

IPC分类号： C07D491/044 ,  A61K31/407 ,  A61P25/18

CPC分类号： C07D491/044

摘要： The invention relates to novel crystalline HCl salts of Asenapine and to methods of their preparation. Furthermore the invention relates to the use of the novel salts in pharmaceutical compositions and the use of the novel salts in the treatment of psychotic diseases or disorders such as schizophrenia and acute mania associated with bipolar disorder.