公开(公告)号：EP4276855A1

公开(公告)日：2023-11-15

申请号：EP22736746.3

申请日：2022-01-05

申请人： Nihon Medi-Physics Co., Ltd. ,  National Institutes for Quantum Science and Technology

发明人： HONDA, Yoshio ,  ITO, Taku ,  ICHINOSE, Jun ,  ICHIKAWA, Hiroaki ,  IMAI, Tomoyuki ,  NAGATSU, Kotaro ,  SUZUKI, Hisashi

IPC分类号： G21G4/08

摘要： An aspect of the present invention relates to a method for producing an 225 Ac solution or a method for producing a medicine using the solution. The method for producing an 225 Ac solution includes a step of irradiating a 226 Ra target with particles to generate two or more actinium radioisotopes (Ac) including at least 225 Ac, a step of dissolving the 226 Ra target after the aforementioned step to obtain a solution (1) that contains 226 Ra and Ac, a step of separating 226 Ra and Ac contained in the solution (1) to obtain a solution (2) that has a higher Ac concentration than the solution (1), a step of allowing Ac contained in the solution (2) other than 225 Ac to decay to obtain a solution (3) containing radium isotopes (Ra) resulting from decay, and a step of separating Ra and Ac contained in the solution (3) to obtain a solution (4) that has a higher 225 Ac concentration than the solution (3), and the solution (4) is used to produce a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex with 225 Ac, and an Nd2 antibody or a targeting agent (excluding Nd2 antibodies).

公开(公告)号：EP4276207A1

公开(公告)日：2023-11-15

申请号：EP21917755.7

申请日：2021-12-27

申请人： Nihon Medi-Physics Co., Ltd. ,  National Institutes for Quantum Science and Technology

发明人： HONDA, Yoshio ,  ITO, Taku ,  ICHINOSE, Jun ,  NAGATSU, Kotaro ,  SUZUKI, Hisashi

IPC分类号： C22B7/00 ,  C22B7/04 ,  C22B60/00 ,  C22B3/06 ,  C22B3/42

摘要： One aspect of the present invention relates to a recovery method of 226 Ra, and the recovery method of 226 Ra includes a step (A1) of immersing a solid-state 226 Ra-containing substance and a carrier having a function of adsorbing 226 Ra ions in a processing solution, and then irradiating the processing solution with ultrasonic waves.

公开(公告)号：EP4184528A1

公开(公告)日：2023-05-24

申请号：EP21842595.7

申请日：2021-07-13

申请人： Nihon Medi-Physics Co., Ltd

发明人： HONDA, Yoshio ,  NATSUSAKO, Masashi ,  ASO, Shunichi

IPC分类号： G21G4/08 ,  C22B60/02 ,  C22B3/24 ,  A61K51/00 ,  B01J20/22 ,  B01J20/34

摘要： A method for producing 225 Ac solution includes steps (I) to (III): a step (I) of passing a solution (1) containing 226 Ra and 225 Ac through a solid-phase extraction agent (a) that contains a compound represented by formula (A) so as to cause the solid-phase extraction agent (a) to retain 225 Ac; a step (II) of passing a liquid containing an eluate (2), which is obtained by eluting the retained 225 Ac from the solid-phase extraction agent (a), through a solid-phase extraction agent (b) that contains a compound represented by formula (B) so as to cause the solid-phase extraction agent (b) to retain 225 Ac; and a step (III) of eluting the retained 225 Ac from the solid-phase extraction agent (b) to obtain an 225 Ac solution.

[m and n each independently represent 0 or 1, and R 1 to R 4 each independently represent a linear or branched C8-C12 alkyl group.]

[R 5 and R 6 each independently represent a C8 alkyl group or a C8 alkoxy group.]