公开(公告)号：EP4368176A1

公开(公告)日：2024-05-15

申请号：EP22837758.6

申请日：2022-07-08

申请人： Nippon Shinyaku Co., Ltd. ,  National University Corporation Kobe University

发明人： SONOKE Satoru ,  FUJIWARA Kae ,  SATOU Youhei ,  WAKAYAMA Tatsushi ,  MASUDA Hirofumi ,  SEKI Ryosuke ,  MATSUBARA Takuma ,  NUMAKURA Yuki ,  OKAMOTO Kentaro ,  TODA Tatsushi ,  IKEDA Mariko ,  KOBAYASHI Kazuhiro

IPC分类号： A61K31/047 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/26 ,  A61P13/12 ,  A61P39/02 ,  C12N15/113

CPC分类号： A61K31/047 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/26 ,  A61P13/12 ,  A61P39/02 ,  C12N15/113

摘要： In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/mL to 400 mg/mL.