公开(公告)号：EP4368176A1

公开(公告)日：2024-05-15

申请号：EP22837758.6

申请日：2022-07-08

申请人： Nippon Shinyaku Co., Ltd. ,  National University Corporation Kobe University

发明人： SONOKE Satoru ,  FUJIWARA Kae ,  SATOU Youhei ,  WAKAYAMA Tatsushi ,  MASUDA Hirofumi ,  SEKI Ryosuke ,  MATSUBARA Takuma ,  NUMAKURA Yuki ,  OKAMOTO Kentaro ,  TODA Tatsushi ,  IKEDA Mariko ,  KOBAYASHI Kazuhiro

IPC分类号： A61K31/047 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/26 ,  A61P13/12 ,  A61P39/02 ,  C12N15/113

CPC分类号： A61K31/047 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/26 ,  A61P13/12 ,  A61P39/02 ,  C12N15/113

摘要： In one embodiment, the object of the present invention is to provide a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, and a method for reducing nephrotoxicity of the pharmaceutical composition. In one embodiment, the present invention relates to a nephrotoxicity reducing agent for a pharmaceutical composition comprising an antisense oligomer, wherein the nephrotoxicity reducing agent comprises a sugar alcohol and is used in an amount such that the concentration of the sugar alcohol in the pharmaceutical composition is 1 mg/mL to 400 mg/mL.

公开(公告)号：EP3118311A1

公开(公告)日：2017-01-18

申请号：EP15761392.8

申请日：2015-03-11

申请人： Nippon Shinyaku Co., Ltd. ,  National Center of Neurology and Psychiatry

发明人： WAKAYAMA Tatsushi ,  SEO Haruna ,  SATOU Youhei ,  TAKEDA Shin'ichi ,  NAGATA Tetsuya

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K31/712 ,  A61K31/7125 ,  A61P21/00 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/314 ,  C12N2310/3233 ,  C12N2320/33

摘要： Provided is a drug that allows highly-efficient skipping of exon 51 in the human dystrophin gene. The present invention provides an antisense oligomer which enables exon 51 in the human dystrophin gene to be skipped.

摘要翻译： 提供了允许高效跳过人肌营养不良蛋白基因中的外显子51的药物。 本发明提供能够跳过人肌营养不良蛋白基因中的外显子51的反义寡聚体。

公开(公告)号：EP3118311B1

公开(公告)日：2018-12-26

申请号：EP15761392.8

申请日：2015-03-11

申请人： Nippon Shinyaku Co., Ltd. ,  National Center of Neurology and Psychiatry

发明人： WAKAYAMA Tatsushi ,  SEO Haruna ,  SATOU Youhei ,  TAKEDA Shin'ichi ,  NAGATA Tetsuya

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K31/712 ,  A61K31/7125 ,  A61P21/00 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/314 ,  C12N2310/3233 ,  C12N2320/33

摘要： Provided is a drug that allows highly-efficient skipping of exon 51 in the human dystrophin gene. The present invention provides an antisense oligomer which enables exon 51 in the human dystrophin gene to be skipped.