公开(公告)号：EP2141149A1

公开(公告)日：2010-01-06

申请号：EP07742277.2

申请日：2007-04-24

申请人： Nippon Soda Co., Ltd.

发明人： SHIBATA, Yasushi ,  IMAGAWA, Tsutomu

IPC分类号： C07D213/61 ,  C07B43/04 ,  C07D401/06

CPC分类号： C07D213/61 ,  C07B43/04 ,  C07C209/06 ,  C07C211/03 ,  C07C211/48 ,  C07C211/62 ,  C07D251/04 ,  C07D257/08 ,  C07D277/20 ,  C07D401/06 ,  C07D401/14 ,  C08G73/0627 ,  C08G73/0644

摘要： The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid.

(wherein A represents an organic group that is either a hydrocarbon group or a heterocyclic group, or said organic group that has a substituent, R represents a hydrogen atom, an organic group that is either a hydrocarbon group or a heterocyclic group, or said organic group that has a substituent, L represents a halogen atom and the like, and n represents an integer of 2 to 20)

摘要翻译： 本发明提供了能够容易地以良好的产率和低成本生产作为农药和药物生产中间体的取代甲胺化合物的方法，并且还提供了其生产中间体。 该方法包括使由式（I）表示的六亚甲基四铵盐化合物与碱反应以获得由式（II）表示的N-亚甲基取代的甲基胺低聚物或两种或更多种低聚物的混合物的步骤，以及 在酸存在下水解由式（II）表示的N-亚甲基取代的甲胺低聚物或两种或更多种低聚物的混合物的步骤。 （其中A表示烃基或杂环基的有机基团或具有取代基的有机基团，R表示氢原子，作为烃基或杂环基的有机基团或所述有机基团 具有取代基的基团，L表示卤素原子等，n表示2〜20的整数）

公开(公告)号：EP0791583B1

公开(公告)日：2001-04-18

申请号：EP96929543.5

申请日：1996-09-06

申请人： NIPPON SODA CO., LTD.

发明人： INOUE, Tsutomu ,  TAKAHASHI, Jun ,  IMAGAWA, Tsutomu ,  HATANAKA, Kazuhiro

IPC分类号： C07D213/61 ,  C07B39/00

CPC分类号： C07D213/89 ,  C07D213/61

公开(公告)号：EP2141149B1

公开(公告)日：2014-10-29

申请号：EP07742277.2

申请日：2007-04-24

申请人： Nippon Soda Co., Ltd.

发明人： SHIBATA, Yasushi ,  IMAGAWA, Tsutomu

IPC分类号： C07D213/61 ,  C07D401/14 ,  C07B43/04 ,  C07D401/06

CPC分类号： C07D213/61 ,  C07B43/04 ,  C07C209/06 ,  C07C211/03 ,  C07C211/48 ,  C07C211/62 ,  C07D251/04 ,  C07D257/08 ,  C07D277/20 ,  C07D401/06 ,  C07D401/14 ,  C08G73/0627 ,  C08G73/0644

摘要： The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. (wherein A represents an organic group that is either a hydrocarbon group or a heterocyclic group, or said organic group that has a substituent, R represents a hydrogen atom, an organic group that is either a hydrocarbon group or a heterocyclic group, or said organic group that has a substituent, L represents a halogen atom and the like, and n represents an integer of 2 to 20)

公开(公告)号：EP2184274A1

公开(公告)日：2010-05-12

申请号：EP08828642.2

申请日：2008-08-27

申请人： Nippon Soda Co., Ltd.

发明人： HAKUTA, Hiroshi ,  IMAGAWA, Tsutomu ,  OOOKA, Hirohito ,  FUKUHARA, Shinya

IPC分类号： C07D221/24 ,  C07B61/00

CPC分类号： C07D221/24 ,  C07B55/00

摘要： There are provided, according to the present invention, a method for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, the method characterized in that a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of the trans- and cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivatives is isomerized in the presence of an aluminum compound represented by a formula Al(OR 1 ) 3 (wherein R 1 represents a hydrocarbon group in which a carbon atom having an oxygen atom bonded thereto is a secondary carbon atom). In the process, a ketone compound may be further added, in addition to the aluminum compound.

摘要翻译： 根据本发明，提供了制备顺式-3-取代-3-氮杂双环[3.2.1]辛-8-醇衍生物的方法，该方法的特征在于反式-3-取代-3-氮杂双环[ 氮杂双环[3.2.1]辛-8-醇衍生物或反式和顺式-3-取代-3-氮杂双环[3.2.1]辛-8-醇衍生物的混合物在所代表的铝化合物 由式Al（OR 1）3表示（其中R 1表示其中键合有氧原子的碳原子为仲碳原子的烃基）。 在该方法中，除了铝化合物之外，还可以加入酮化合物。

公开(公告)号：EP2650282B1

公开(公告)日：2017-06-07

申请号：EP13175480.6

申请日：2007-04-24

申请人： NIPPON SODA CO., LTD.

发明人： SHIBATA, Yasushi ,  IMAGAWA, Tsutomu

IPC分类号： C07D213/61 ,  C07B43/04 ,  C07D401/06 ,  C07D401/14 ,  C07D257/08 ,  C07D277/20

CPC分类号： C07D213/61 ,  C07B43/04 ,  C07C209/06 ,  C07C211/03 ,  C07C211/48 ,  C07C211/62 ,  C07D251/04 ,  C07D257/08 ,  C07D277/20 ,  C07D401/06 ,  C07D401/14 ,  C08G73/0627 ,  C08G73/0644

摘要： The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. (wherein A represents an organic group that is either a hydrocarbon group or a heterocyclic group, or said organic group that has a substituent, R represents a hydrogen atom, an organic group that is either a hydrocarbon group or a heterocyclic group, or said organic group that has a substituent, L represents a halogen atom and the like, and n represents an integer of 2 to 20)

公开(公告)号：EP2184274B1

公开(公告)日：2012-04-18

申请号：EP08828642.2

申请日：2008-08-27

申请人： Nippon Soda Co., Ltd.

发明人： HAKUTA, Hiroshi ,  IMAGAWA, Tsutomu ,  OOOKA, Hirohito ,  FUKUHARA, Shinya

IPC分类号： C07B55/00

CPC分类号： C07D221/24 ,  C07B55/00

摘要： Disclosed is a process for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, which is characterized by isomerizing a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative and a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative in the presence of an aluminum compound represented by the formula: Al(OR1)3 [wherein R1 represents a hydrocarbon group in which the carbon having an oxygen atom bound thereto is a secondary carbon]. In the process, a ketone compound may be further added, in addition to the aluminum compound.

公开(公告)号：EP2058303B1

公开(公告)日：2010-08-18

申请号：EP07829479.0

申请日：2007-10-10

申请人： Nippon Soda Co., Ltd.

发明人： OOOKA, Hirohito ,  SHIBATA, Yasushi ,  INOUE, Hiroki ,  IMAGAWA, Tsutomu

IPC分类号： C07D221/22 ,  C07D491/113

CPC分类号： C07D221/22 ,  C07D221/24 ,  C07D491/113

摘要： Disclosed is a method for producing a piperidin-4-one derivative which is useful as an intermediate for agricultural chemicals or pharmaceutical products. Specifically, a piperidin-4-one derivative represented by the formula (III-a) or (III-b) below is produced by reacting a cyclic bis(aminol) ether compound represented by the formula (I) below and an acetone derivative represented by the formula (II) below in the presence of at least one substance selected from the group consisting of protonic acids, Lewis acids, acid halides and dialkyl sulfuric acids.

公开(公告)号：EP2058303A1

公开(公告)日：2009-05-13

申请号：EP07829479.0

申请日：2007-10-10

申请人： Nippon Soda Co., Ltd.

发明人： OOOKA, Hirohito ,  SHIBATA, Yasushi ,  INOUE, Hiroki ,  IMAGAWA, Tsutomu

IPC分类号： C07D221/22 ,  C07D491/113

CPC分类号： C07D221/22 ,  C07D221/24 ,  C07D491/113

摘要： Provided is a method for producing a piperidin-4-one derivative useful as an intermediate for agricultural chemicals or pharmaceutical products. A piperidin-4-one derivative represented by formula (III-a) or formula (III-b) is produced by reacting a cyclic bis(aminol)ether compound represented by formula (I) and an acetone derivative represented by formula (II) in the presence of at least one substance selected from the group consisting of protonic acids, Lewis acids, acid halides and dialkyl sulfuric acids.

摘要翻译： 提供可用作农药或药品的中间体的哌啶-4-酮衍生物的制造方法。 由式（I-a）或式（III-b）表示的哌啶-4-酮衍生物由式（I）表示的环状双（氨基醇）醚化合物与由式（II）表示的丙酮衍生物反应制备， 在至少一种选自质子酸，路易斯酸，酰卤和二烷基硫酸的物质存在下进行。

公开(公告)号：EP0791583A1

公开(公告)日：1997-08-27

申请号：EP96929543.5

申请日：1996-09-06

申请人： NIPPON SODA CO., LTD.

发明人： INOUE, Tsutomu ,  TAKAHASHI, Jun ,  IMAGAWA, Tsutomu ,  HATANAKA, Kazuhiro

IPC分类号： C07D213/61

CPC分类号： C07D213/89 ,  C07D213/61

摘要： The present invention is directed to methods for manufacturing 3-(aminomethyl)-6-chloropyridines represented by a general formula [II];
wherein R 2 represents hydrogen or a lower alkyl and R 3 represents hydrogen, a lower alkyl or an halogen atom, characterized in that the compound represented by the general formula [II] is manufactured by allowing 3-(substituted-aminomethyl)pyridine 1-oxide represented by a general formula [I];
wherein R 1 represents alkyl, aryl, aralkyl or alkoxy, R 2 and R 3 are as described above, to react with a base represented by a general formula [a];

        R' R'' R''' N     [a]

wherein R', R'' and R''' may be the same or different one another and represent each independently a lower alkyl or an aromatic group, or R', R'', R''' and N may form together an optionally-substituted pyridine ring, in the presence of an electrophilic reagent having at least one chlorine atom, and subsequently treating the reaction product with hydrogen chloride and water.
The compounds manufactured according to the present invention are useful as the raw materials used for the manufacturing of agricultural chemicals and pharmaceuticals, and particularly useful for the raw materials for manufacturing insecticides.

摘要翻译： 本发明涉及制备由通式ÄIIÜ表示的3-（氨基甲基）-6-氯吡啶的方法; 其中R 2表示氢或低级烷基，R 3表示氢，低级烷基或卤素原子，其特征在于通式Ⅻ所表示的化合物是通过使3-（取代的 - 氨基甲基）吡啶1-氧化物，由通式ÄIÜ表示; 其中R 1表示烷基，芳基，芳烷基或烷氧基，R 2和R 3如上所述，与由通式ÄaÜ表示的碱反应; R'R“R”'，其中R'，R“和R”'可以彼此相同或不同，并且各自独立地表示低级烷基或芳基，或者R'，R“ R“和N可以在具有至少一个氯原子的亲电试剂的存在下一起形成任选取代的吡啶环，随后用氯化氢和水处理反应产物。 根据本发明制造的化合物可用作农药和药物制造的原料，特别适用于制造杀虫剂的原料。