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1.发明授权3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS 有权作为血管生成素受体激活剂的3-烷基肼基取代的异戊二烯基化合物
公开(公告)号：EP1636192B1
公开(公告)日：2014-01-15
申请号：EP04736117.5
申请日：2004-06-04
发明人： OWADA, Shingo, c/o Nissan Chemical Industries, Ltd , IWAMOTO, S., c/o Nissan Chemical Industries, Ltd. , YANAGIHARA, K., Nissan Chemical Industries, Ltd. , MIYAJI, Katsuaki, Nissan Chemical Industries, Ltd. , NAKAMURA, T., c/o Nissan Chemical Industries, Ltd. , ISHIWATA, N., c/o Nissan Chemical Industries, Ltd. , HIROKAWA, Yutaka, Nissan Chemical Industries, Ltd.
IPC分类号： C07D231/18 , C07D333/32 , A61K31/415 , A61K31/381 , A61P7/00 , A61P35/00
CPC分类号： C07D417/12 , C07D231/18 , C07D295/192 , C07D333/32 , C07D333/38 , C07D403/12 , C07D409/12
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2.发明授权3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS 有权3-取代的杂芳基ALKYLIDENEHYDRAZINO ALS THROMBOPOIETINRECEPTOR ACTIVATION GATES
公开(公告)号：EP1636192B9
公开(公告)日：2015-07-01
申请号：EP04736117.5
申请日：2004-06-04
发明人： OWADA, Shingo, c/o Nissan Chemical Industries, Ltd , IWAMOTO, S., c/o Nissan Chemical Industries, Ltd. , YANAGIHARA, K., Nissan Chemical Industries, Ltd. , MIYAJI, Katsuaki, Nissan Chemical Industries, Ltd. , NAKAMURA, T., c/o Nissan Chemical Industries, Ltd. , ISHIWATA, N., c/o Nissan Chemical Industries, Ltd. , HIROKAWA, Yutaka, Nissan Chemical Industries, Ltd.
IPC分类号： C07D231/18 , C07D333/32 , A61K31/415 , A61K31/381 , A61P7/00 , A61P35/00
CPC分类号： C07D417/12 , C07D231/18 , C07D295/192 , C07D333/32 , C07D333/38 , C07D403/12 , C07D409/12
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3.发明公开3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS 有权作为血管生成素受体激活剂的3-烷基肼基取代的异戊二烯基化合物
公开(公告)号：EP1636192A1
公开(公告)日：2006-03-22
申请号：EP04736117.5
申请日：2004-06-04
发明人： OWADA, Shingo, c/o Nissan Chemical Industries, Ltd , IWAMOTO, S., c/o Nissan Chemical Industries, Ltd. , YANAGIHARA, K., Nissan Chemical Industries, Ltd. , MIYAJI, Katsuaki, Nissan Chemical Industries, Ltd. , NAKAMURA, T., c/o Nissan Chemical Industries, Ltd. , ISHIWATA, N., c/o Nissan Chemical Industries, Ltd. , HIROKAWA, Yutaka, Nissan Chemical Industries, Ltd.
IPC分类号： C07D231/18 , C07D333/32 , A61K31/415 , A61K31/381 , A61P7/00 , A61P35/00
CPC分类号： C07D417/12 , C07D231/18 , C07D295/192 , C07D333/32 , C07D333/38 , C07D403/12 , C07D409/12
摘要： A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14; aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10; alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14; aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（1）表示的化合物：其中A是氮原子或CR4，B是氧原子，硫原子或NR9（条件是当A是氮原子时，B不是NH），R1是C2 -14; 芳基，L1是键，CR10R11，氧原子，硫原子或NR12，X是OR13，SR13或NR14NR15，R2是氢原子，甲酰基，C1-10; 烷基等，L2是键等，L3是键，CR17R18，氧原子，硫原子或NR19，L4是键，CR20R21，氧原子，硫原子或NR22，Y是 氧原子，硫原子或NR 23，并且R 3是C 2-14; 芳基，该化合物的互变异构体，前药或药学上可接受的盐或其溶剂化物。
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