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1.发明公开NOVEL LIPID-TRIPEPTIDE BASED HYDROGEL-FORMING AGENT AND HYDROGEL 有权关于HYDROGELBILDENDES MITTEL AUF LIPID-TRIPEPTID-BASIS UND HYDROGEL
公开(公告)号：EP2180027A1
公开(公告)日：2010-04-28
申请号：EP08790895.0
申请日：2008-07-04
CPC分类号： B01F17/005 , A23L29/20 , A61K8/042 , A61K8/64 , A61Q19/00 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： There is provided a hydrogelator that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A hydrogelator comprising a lipid peptide represented by Formula (1):
(where R 1 represents an aliphatic group having 9 to 21 carbon atoms;
R 2 , R 3 and R 4 independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atom(s) which may have a branched chain having 1 or 2 carbon atom(s), a phenylmethyl group or a -(CH 2 ) n -X group, and at least one of R 2 , R 3 and R 4 represents a -(CH 2 ) n -X group; n represents the number of 1 to 4; X represents an amino group, a guanidino group, a -CONH 2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which may have 1 to 3 nitrogen atom(s)) or a salt thereof, and a hydrogel comprising the hydrogelator.摘要翻译： 提供一种水凝胶化剂，其能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶，以及具有高环境适应性，生物相容性和生物降解性的水凝胶。 包含由式（1）表示的脂质肽的水凝胶剂：（其中R 1表示具有9-21个碳原子的脂族基团; R 2，R 3和R 4独立地表示氢原子，具有1至4个碳原子的烷基 可具有1或2个碳原子的支链的原子，苯基甲基或 - （CH 2）n -X基，R 2，R 3和R 4中的至少一个表示 - （CH 2）n -X基; n表示1至4的数; X表示氨基，胍基，-CONH 2基或5元环，6元环或稠合杂环 由5元环和可以具有1〜3个氮原子的6元环组成的环）或其盐，以及包含该水凝胶体的水凝胶。
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公开(公告)号：EP2172475B1
公开(公告)日：2015-06-03
申请号：EP08790893.5
申请日：2008-07-04
CPC分类号： C07K7/06 , C07K5/1008 , C07K5/101 , C07K5/1016 , C07K5/1019 , C07K5/1024
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公开(公告)号：EP2180027B1
公开(公告)日：2011-10-26
申请号：EP08790895.0
申请日：2008-07-04
CPC分类号： B01F17/005 , A23L29/20 , A61K8/042 , A61K8/64 , A61Q19/00 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： Disclosed is a hydrogel-forming agent, only a small amount of which enables to form a hydrogel over a wide pH range from acidic to alkaline conditions. Also disclosed is a hydrogel exhibiting high environmental suitability and biocompatibility, while having biodegradability. Specifically disclosed are a hydrogel-forming agent composed of a lipid-peptide represented by the formula (1) below or a salt thereof, and a hydrogel. (1) (In the formula, R1 represents an aliphatic group having 9-21 carbon atoms; R2, R3 and R4 independently represent a hydrogen atom, an alkyl group having 1-4 carbon atoms which may have a branched chain with 1 or 2 carbon atoms, a phenylmethyl group or a -(CH2)n-X group, provided that at least one of R2, R3 and R4 represents a -(CH2)n-X group; n represents a number of 1-4; X represents an amino group, a guanidino group, a -CONH2 group, or a five-membered or six-membered ring which may have 1-3 nitrogen atoms or a fused heterocyclic ring composed of a five-membered and a six-membered ring.)
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公开(公告)号：EP2172475A1
公开(公告)日：2010-04-07
申请号：EP08790893.5
申请日：2008-07-04
CPC分类号： C07K7/06 , C07K5/1008 , C07K5/101 , C07K5/1016 , C07K5/1019 , C07K5/1024
摘要： There is provided a lipid peptide that is capable of forming a hydrogel with an extremely small amount thereof over a liquid property range from acidic to alkaline, and a hydrogel having high environmental suitability, biocompatibility and biodegradability. A lipid peptide represented by Formula (1):
(where R 1 represents an aliphatic group having 9 to 23 carbon atoms;
R 2 , R 3 , R 4 and R 5 independently represent a hydrogen atom, an alkyl group having 1 to 7 carbon atom(s) which optionally has a branched chain having 1 to 3 carbon atom(s), a phenylmethyl group, a phenylethyl group or a -(CH 2 ) n -X group, and at least one of R 2 , R 3 , R 4 and R 5 represents a -(CH 2 ) n -X group;
n represents the number of 1 to 4; X represents an amino group, a guanidino group, a -CONH 2 group or a 5-membered ring, a 6-membered ring or a fused heterocyclic ring composed of a 5-membered ring and a 6-membered ring which optionally have 1 to 3 nitrogen atom(s); and m represents 1 or 2), and a hydrogel comprising the lipid peptide.摘要翻译： 提供了能够在从酸性到碱性的液体性质范围内形成极少量的水凝胶的脂质肽和具有高环境适应性，生物相容性和生物降解性的水凝胶。 由式（1）表示的脂质肽：其中，R 1表示碳原子数为9〜23的脂肪族基团，R 2，R 3，R 4和R 5分别独立地表示氢原子，碳原子数为1〜7的烷基 任选具有1至3个碳原子的支链的原子，苯基甲基，苯乙基或 - （CH 2）n -X基团，以及R 2，R 3， R 4和R 5表示 - （CH 2）n -X基; n表示1〜4的数; X表示氨基，胍基，-CONH 2基或5元环，6 由5元环和6元环组成的稠合杂环，其任选具有1至3个氮原子; m表示1或2）和包含脂质肽的水凝胶。
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