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    NITRIC OXIDE ENHANCING ANGIOTENSIN II ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE
    1.
    发明公开
    NITRIC OXIDE ENHANCING ANGIOTENSIN II ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
    氮氧化物加固拮抗血管紧张素II化合物，组合物及使用方法

    公开(公告)号：EP1922069A2

    公开(公告)日：2008-05-21

    申请号：EP06800882.0

    申请日：2006-08-07

    申请人： Nitromed, Inc.

    发明人： GARVEY, David, S. ,  CAI, Xiong ,  FANG, Xinqin ,  RANATUNGE, Ramani, R. ,  WEY, Shiow-Jyi ,  ZHAI, Hai-Xiao

    IPC分类号： A61K31/4245 ,  A61K31/433 ,  A61K31/42

    CPC分类号： C07D257/04 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D471/04

    摘要： The invention describes compositions and kits comprising at least one nitric oxide enhancing angiotensin II antagonist compound, or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitric oxide enhancing angiotensin II antagonist compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating peripheral vascular diseases; (m) treating portal hypertension (o) treating central nervous system disorders; (p) treating metabolic syndrome; and (q) treating hyperlipidemia. The nitric oxide enhancing angiotensin II antagonist compounds comprise at least one nitric oxide enhancing group linked to the angiotensin II antagonist compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.

    ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN II ANTAGONISTS, COMPOSITIONS AND METHODS OF USE
    2.
    发明公开
    ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN II ANTAGONISTS, COMPOSITIONS AND METHODS OF USE 审中-公开
    有机氮氧化物增强血管紧张素Ⅱ拮抗剂，组合物和盐的使用方法

    公开(公告)号：EP1861093A2

    公开(公告)日：2007-12-05

    申请号：EP06737602.0

    申请日：2006-03-09

    申请人： Nitromed, Inc.

    发明人： GARVEY, David, S. ,  CAI, Xiong ,  LIN, Chia-En ,  RANATUNGE, Ramini, R. ,  STEVENSON, Cheri, A. ,  WEY, Shiow-Jyi

    IPC分类号： A61K31/41 ,  C07D257/04

    CPC分类号： C07D257/04 ,  C07C291/02 ,  C07D213/82

    摘要： The invention describes compositions and kits comprising at least one organic nitric oxide enhancing salt of an angiotensin π antagonist, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating peripheral vascular diseases; (m) treating portal hypertension; (n) treating ophthalmic disorders; (o) treating metabolic syndrome; and (p) treating hyperlipidemia. The organic nitric oxide enhancing compounds that form salts with the angiotensin II antagonists are organic nitrates, organic nitrites, nitrosothiols, thionitrites, thionitrates, NONOates, heterocyclic nitric oxide donors and/or nitroxides. The heterocyclic nitric oxide donors are furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.