公开(公告)号：EP1123509A2

公开(公告)日：2001-08-16

申请号：EP99971091.6

申请日：1999-10-22

申请人： Nitsch, Roger

发明人： NITSCH, Roger ,  GROWDON, John

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/8139 ,  G01N2800/2821

摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.