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    Biomarkers for the prognosis of ischemic stroke
    3.
    发明公开
    Biomarkers for the prognosis of ischemic stroke 审中-公开
    Biomarker zur Prognose vonischämischemSchlaganfall

    公开(公告)号：EP2725360A1

    公开(公告)日：2014-04-30

    申请号：EP12382411.2

    申请日：2012-10-24

    申请人： Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca

    发明人： Garcia-Berrocoso, Teresa ,  Montaner Villalonga, Joan

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/4703 ,  G01N2333/8139 ,  G01N2800/2871 ,  G01N2800/52

    摘要： The invention relates to methods for determining the clinical outcome of a patient suffering ischemic stroke, for designing an individual therapy and for diagnosing a silent cerebrovascular disease comprising determining the levels of a marker selected from gelsolin, CysA, DPYSL2 or a combination thereof, the altered expression of which in relation to a reference value allows determining the clinical outcome of a patient suffering ischemic stroke, designing for designing an individual therapy or diagnosing a silent cerebrovascular disease. Furthermore, the invention relates to a kit comprising a reagent for detecting the level of a marker selected from gelsolin, CysA, DPYSL2 or a combination thereof and to the use of the said kit in the methods of the invention.

    摘要翻译： 本发明涉及用于确定患有缺血性卒中的患者的临床结果的方法，用于设计个体治疗和用于诊断静息脑血管疾病的方法，包括确定选自凝溶胶蛋白，CysA，DPYSL2或其组合的标志物的水平，所述改变的 相对于参考值的表达允许确定患有缺血性卒中的患者的临床结果，设计用于设计个体治疗或诊断静息脑血管疾病的临床结果。 此外，本发明涉及一种试剂盒，其包含用于检测选自凝溶胶蛋白，CysA，DPYSL2或其组合的标记物的水平的试剂，以及本发明方法中所述试剂盒的用途。

    EXOSOMAL BIOMARKERS FOR PREDICTING CARDIOVASCULAR EVENTS
    4.
    发明公开
    EXOSOMAL BIOMARKERS FOR PREDICTING CARDIOVASCULAR EVENTS 审中-公开
    外来体生物标志物预测心血管事件

    公开(公告)号：EP2676141A2

    公开(公告)日：2013-12-25

    申请号：EP12722288.3

    申请日：2012-02-17

    申请人： Cavadis B.V.

    发明人： DE KLEIJN, Dominique ,  PASTERKAMP, Gerard ,  TIMMERS, Leonardus ,  SZE, Siu Kwan

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/78 ,  G01N2333/8121 ,  G01N2333/8139 ,  G01N2800/32

    摘要： The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in an exosome sample from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. Alternatively, the exosomes are present in a body fluid, in particular serum. The biomarker is selected- from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2, Serpin Gl or any combination of two or more of these proteins. The invention further relates to a method of diagnosing the occurrence of acute coronary syndrome in a subject, comprising determining the presence of a biomarker that is indicative of the occurrence of acute coronary syndrome in an exosome sample from the subject. In this method the biomarker is selected from Serpin F2, CD14, Cystatin C or combinations thereof.

    BIOMARKER FOR DIAGNOSIS OF LIVER DISEASE
    10.
    发明公开
    BIOMARKER FOR DIAGNOSIS OF LIVER DISEASE 审中-公开
    BIOMARKER ZUR DIAGNOSE EINER LEBERERKRANKUNG

    公开(公告)号：EP2216651A1

    公开(公告)日：2010-08-11

    申请号：EP08840152.6

    申请日：2008-10-20

    申请人： Miyazaki Prefectural Industrial Support Foundation ,  Kagoshima University ,  Chugai Seiyaku Kabushiki Kaisha

    发明人： TSUBOUCHI, Hirohito ,  UTO, Hirofumi ,  OKANOUE, Takeshi ,  ISHIDA, Yo-ichi ,  SATO, Yuko ,  SUDO, Masayuki

    IPC分类号： G01N33/53 ,  C07K16/18

    CPC分类号： G01N33/6893 ,  G01N2333/8139 ,  G01N2800/085

    摘要： Disclosed are: a marker for the diagnosis of a liver disease, which can determine the disease in a simple manner; an antibody directed agaist the marker; a diagnostic agent; a diagnosis method; and a method for marker detection in blood or serum. Proteome analysis revealed that quantities of the full-length kininogen and three partial peptides therof (sequence A: postion-440 to position-456, sequence B: postion-439 to postion-456, and sequence C: position-43 to position-456) in sera of patients with non-alcoholic fatty liver disease are significantly different from those in sera of healthy individuals; and a diagnostic agent and a detecting method for the non-alcoholic fatty liver disease that can be conveniently used for medical examination are established. The use of a combination of a kininogen-based marker and a C4-based marker (the full length sequence or partial peptides thereof) enables identification of chronic hepatitis and an asymptomatic virus carrier, as well as non-alcoholic fatty liver disease.

    摘要翻译： 公开的是：用于诊断肝脏疾病的标志物，其可以以简单的方式确定疾病; 标记抗体; 诊断剂 诊断方法; 以及血液或血清中标记物检测的方法。 蛋白质组分析显示，全长激肽原和三个部分肽（序列A：位置-440至位置-456，序列B：位置-439至位点-456以及序列C：位置43至位置-456）的量 ）与非酒精性脂肪性肝病患者的血清显着不同于健康人血清; 建立了可以方便地用于体格检查的非酒精性脂肪肝疾病的诊断剂和检测方法。 使用基于激肽原的标记物和基于C4的标记物（其全长序列或部分肽）的组合能够鉴定慢性肝炎和无症状病毒载体以及非酒精性脂肪肝疾病。