公开(公告)号：EP2505194A3

公开(公告)日：2012-10-10

申请号：EP12161080.2

申请日：2012-03-23

申请人： Nitto Denko Corporation

发明人： Enomoto, Kazumi ,  Kuroda, Hidetoshi ,  Satoda, Shiro ,  Nakamura, Koji ,  Takita, Tomohito

IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K31/465

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/465

摘要： An object of the present invention is to provide a nicotine-containing patch preparation which enables to suppress degradation of nicotine and coloring of the patch preparation. The present invention provides a patch preparation comprising a support and an adhesive layer on its at least one surface, wherein the adhesive layer comprises an adhesive polymer, nicotine and a stabilizer, and the stabilizer is at least one kind selected from the group consisting of butylhydroxyanisole (BHA), propyl gallate (PGA), dibutylhydroxytoluene (BHT) and 2-mercaptobenzimidazole (MBT).

公开(公告)号：EP2505194A2

公开(公告)日：2012-10-03

申请号：EP12161080.2

申请日：2012-03-23

申请人： Nitto Denko Corporation

发明人： Enomoto, Kazumi ,  Kuroda, Hidetoshi ,  Satoda, Shiro ,  Nakamura, Koji ,  Takita, Tomohito

IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K31/465

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/465

摘要： An object of the present invention is to provide a nicotine-containing patch preparation which enables to suppress degradation of nicotine and coloring of the patch preparation. The present invention provides a patch preparation comprising a support and an adhesive layer on its at least one surface, wherein the adhesive layer comprises an adhesive polymer, nicotine and a stabilizer, and the stabilizer is at least one kind selected from the group consisting of butylhydroxyanisole (BHA), propyl gallate (PGA), dibutylhydroxytoluene (BHT) and 2-mercaptobenzimidazole (MBT).

摘要翻译： 本发明的目的是提供一种含尼古丁贴剂制剂，其能够抑制尼古丁的降解和贴剂制剂的着色。 本发明提供一种贴剂制剂，其包含载体和在其至少一个表面上的粘合剂层，其中所述粘合剂层包含粘合剂聚合物，尼古丁和稳定剂，并且所述稳定剂为选自以下的至少一种：丁基羟基茴香醚 （BHA），没食子酸丙酯（PGA），二丁基羟基甲苯（BHT）和2-巯基苯并咪唑（MBT）。