公开(公告)号：EP2538223A3

公开(公告)日：2013-04-24

申请号：EP12185057.2

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N33/542 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is decorin and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

摘要翻译： 一种用于定量包含通过蛋白酶切割动脉粥样硬化斑块的蛋白质而形成的新表位的肽片段的生物测定法，其中所述蛋白质是核心蛋白聚糖，并且所述方法包括使样品例如尿液或血清与抗体反应 与新表位结合，并测定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定可预测心血管疾病事件的风险。

公开(公告)号：EP2538218A3

公开(公告)日：2013-04-24

申请号：EP12185056.4

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/542 ,  C12Q1/37 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque, wherein the protein is biglycan and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

公开(公告)号：EP2538221A2

公开(公告)日：2012-12-26

申请号：EP12185050.7

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N33/542 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is versican and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

摘要翻译： 一种用于定量包含通过蛋白酶切割动脉粥样硬化斑块的蛋白质而形成的新表位的肽片段的生物测定的方法，其中所述蛋白质为多功能蛋白并且所述方法包括使样品如尿液或血清与抗体反应 与新表位结合，并测定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定可预测心血管疾病事件的风险。

公开(公告)号：EP2538221A3

公开(公告)日：2013-04-24

申请号：EP12185050.7

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N33/542 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is versican and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

公开(公告)号：EP2538222A8

公开(公告)日：2013-02-27

申请号：EP12185053.1

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C07K14/47 ,  C12Q1/37 ,  G01N33/542

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is CRP and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

公开(公告)号：EP2538222A3

公开(公告)日：2013-04-24

申请号：EP12185053.1

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C07K14/47 ,  C12Q1/37 ,  G01N33/542

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is CRP and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

摘要翻译： 一种用于定量包含通过蛋白酶切割动脉粥样硬化斑块的蛋白质而形成的新表位的肽片段的生物测定法，其中所述蛋白质是CRP并且所述方法包括使样品如尿液或血清与抗体反应 与新表位结合，并测定所述免疫结合配偶体与所述样品中肽片段的结合水平。 该测定可预测心血管疾病事件的风险。

公开(公告)号：EP2538223A8

公开(公告)日：2013-02-27

申请号：EP12185057.2

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/68 ,  C12Q1/37 ,  G01N33/542 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque by a proteinase, wherein the protein is decorin and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

公开(公告)号：EP2538218A8

公开(公告)日：2013-02-27

申请号：EP12185056.4

申请日：2008-11-04

申请人： Nordic Bioscience A/S

发明人： Karsdal, Morten ,  Qvist, Per ,  Barascuk, Natasha

IPC分类号： G01N33/542 ,  C12Q1/37 ,  C07K14/47

CPC分类号： G01N33/6878 ,  C07K14/77 ,  C07K14/775 ,  C07K14/78 ,  C12Q1/37 ,  G01N33/542 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/52

摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque, wherein the protein is biglycan and said method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.

摘要翻译： 一种用于定量包含通过切割动脉粥样硬化斑块的蛋白质形成的新表位的肽片段的生物测定法，其中所述蛋白质是双糖链蛋白聚糖，并且所述方法包括使样品例如尿液或血清与可与新霉素反应的抗体 并确定所述免疫结合配偶体与所述样品中的肽片段的结合水平。 该测定可预测心血管疾病事件的风险。