公开(公告)号：EP3039733A1

公开(公告)日：2016-07-06

申请号：EP14840167.2

申请日：2014-08-29

申请人： Northeastern University

发明人： GOLUCH, Edgar D. ,  SISMAET, Hunter J. ,  WEBSTER, Thaddaeus A.

IPC分类号： H01M4/02

CPC分类号： G01N27/3275 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/0896 ,  G01N27/3277 ,  G01N33/48728 ,  G01N33/48735 ,  G01N2333/21

摘要： Devices for electrochemical measurement of a redox active substance secreted by a cell in a liquid sample are provided. The devices include one or more electrodes and a matrix capable of releasing a chemical agent that stimulates secretes of the redox active substance by the cell. In some embodiments, the devices include a nanofluidic electrode assembly in which the one or more electrodes are disposed within a nanofluidic channel. Methods of fabricating the devices and methods of using the devices to detect secretion of a redox active substance by a cell are also provided.

摘要翻译： 提供了用于电化学测量由液体样品中的细胞分泌的氧化还原活性物质的装置。 这些装置包括一个或多个电极和能够释放刺激细胞分泌的氧化还原活性物质的化学试剂的基质。 在一些实施方案中，所述装置包括其中所述一个或多个电极设置在纳米流体通道内的纳米流体电极组件。 还提供了制造装置的方法和使用该装置来检测细胞分泌的氧化还原活性物质的方法。

公开(公告)号：EP3194373A2

公开(公告)日：2017-07-26

申请号：EP15841956.4

申请日：2015-09-16

申请人： Northeastern University

发明人： GOLUCH, Edgar D. ,  SISMAET, Hunter J. ,  WEBSTER, Thaddaeus A.

IPC分类号： C07D241/26

CPC分类号： C12Q1/12 ,  A61K31/496 ,  A61K38/12 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/02 ,  B01L2300/0636 ,  B01L2300/0645 ,  C12M1/34 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/22 ,  G01N27/327 ,  G01N27/48 ,  G01N33/48707 ,  G01N33/48735 ,  G01N2333/21

摘要： Methods and devices for monitoring the viability of a biofilm comprising Pseudomonas Aeruginosa bacteria are provided by detecting pyocyanin. The invention relates to electrochemical methods and devices that offer a simple and inexpensive alternative for immediate identification of bacterial infection due to the presence of Pseudomonas aeruginosa. In some embodiments, an inexpensive, disposable electrochemical sensor can be used to rapidly screen for the presence of P. aeruginosa in clinical wound effluent samples.

摘要翻译： 通过检测绿脓菌素来提供用于监测包含绿脓假单胞菌细菌的生物膜的活力的方法和装置。

公开(公告)号：EP3039733B1

公开(公告)日：2018-11-21

申请号：EP14840167.2

申请日：2014-08-29

申请人： Northeastern University

发明人： GOLUCH, Edgar D. ,  SISMAET, Hunter J. ,  WEBSTER, Thaddaeus A.

IPC分类号： H01M4/02 ,  G01N27/327 ,  G01N33/487

CPC分类号： G01N27/3275 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/0896 ,  G01N27/3277 ,  G01N33/48728 ,  G01N33/48735 ,  G01N2333/21

摘要： Devices for electrochemical measurement of a redox active substance secreted by a cell in a liquid sample are provided. The devices include one or more electrodes and a matrix capable of releasing a chemical agent that stimulates secretes of the redox active substance by the cell. In some embodiments, the devices include a nanofluidic electrode assembly in which the one or more electrodes are disposed within a nanofluidic channel. Methods of fabricating the devices and methods of using the devices to detect secretion of a redox active substance by a cell are also provided.