公开(公告)号：EP1812408B1

公开(公告)日：2013-10-09

申请号：EP05817588.6

申请日：2005-11-02

申请人： Northwestern University ,  Université de Strasbourg ,  Centre National de la Recherche Scientifique

发明人： WATTERSON, D. Martin ,  VAN ELDIK, Linda ,  HAIECH, Jacques ,  HIBERT, Marcel ,  BOURGUIGNON, Jean-jacques ,  VELENTZA, Anastasia ,  HU, Wenhui ,  ZASADZKI, Magdelena

IPC分类号： A61K31/50 ,  C07D403/12 ,  A61K31/502 ,  C07D401/04 ,  A61P25/28 ,  A61P37/00

CPC分类号： C07D401/12 ,  A61K31/502 ,  C07D237/20 ,  C07D237/24 ,  C07D237/34 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07H19/16

摘要： The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. Compounds of Formula Ia or Ib or wherein R is a substituted amino group, R 2 is an unsaturated 5 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, R 3 , R 4 , R 5 , and R 6 are hydrogen, and R 7 is absent; or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及新颖的化合物，组合物和制备和使用它们的方法。 特别地，本发明提供哒嗪化合物和/或相关杂环衍生物，包含其的组合物，以及制备和使用哒嗪化合物和/或相关杂环衍生物的方法及其组合物，用于调节细胞途径（例如，信号转导 途径），用于治疗或预防炎性疾病（如阿尔茨海默病），用于研究，药物筛选和治疗应用。 式Ia或Ib的化合物或其中R是取代的氨基，R 2是含有1至4个氮原子的不饱和5至6元杂单环基团，R 3，R 4，R 5和R 6是氢，和 R 7不存在 或其药学上可接受的盐。

公开(公告)号：EP1812007B1

公开(公告)日：2011-09-07

申请号：EP05823123.4

申请日：2005-11-02

申请人： Northwestern University ,  Universite De Strasbourg ,  Centre National de la Recherche Scientifique

发明人： WATTERSON, D. Martin ,  VAN ELDIK, Linda ,  HAIECH, Jacques ,  HIBERT, Marcel ,  BOURGUIGNON, Jean-jacques ,  VELENTZA, Anastasia ,  HU, Wenhui ,  ZASADZKI, Magdelena

IPC分类号： A61K31/535 ,  C07D413/00 ,  A61K31/50 ,  C07D487/00 ,  A61K31/495 ,  C07D237/26 ,  A01N43/58 ,  C07D237/36 ,  A01N43/60

CPC分类号： C07D403/12 ,  C07D237/36 ,  C07D401/12 ,  C07D401/14 ,  C07D498/06

摘要： The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

公开(公告)号：EP1812408A2

公开(公告)日：2007-08-01

申请号：EP05817588.6

申请日：2005-11-02

申请人： Northwestern University ,  Université Louis Pasteur de Strasbourg

发明人： WATTERSON, D. Martin ,  VAN ELDIK, Linda ,  HAIECH, Jacques ,  HIBERT, Marcel ,  BOURGUIGNON, Jean-jacques ,  VELENTZA, Anastasia ,  HU, Wenhui ,  ZASADZKI, Magdelena

IPC分类号： C07D237/00 ,  C07D409/00 ,  C07D237/02 ,  A01N43/58 ,  C07D403/00 ,  A61K31/50 ,  C07D405/00 ,  A61K31/4965

CPC分类号： C07D401/12 ,  A61K31/502 ,  C07D237/20 ,  C07D237/24 ,  C07D237/34 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07H19/16

摘要： The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications. Compounds of Formula Ia or Ib or wherein R is a substituted amino group, R 2 is an unsaturated 5 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atoms, R 3 , R 4 , R 5 , and R 6 are hydrogen, and R 7 is absent; or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2015751A2

公开(公告)日：2009-01-21

申请号：EP07776443.9

申请日：2007-04-27

申请人： Northwestern University

发明人： WATTERSON, Martin ,  VAN ELDIK, Linda ,  HU, Wenhui

IPC分类号： A61K31/506 ,  C07D403/12 ,  A61P25/00 ,  A61P25/28

CPC分类号： A61K31/506 ,  C07D403/12

摘要： The invention relates to stable and substantially purified synthetic pharmaceutically acceptable acid addition salts of pyridazine compounds of the formula I wherein R10 is hydrogen, hydroxyl, alkyl, alkoxy, alkenyl, alkynyl, alkylene, aryl, heteroaryl, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, carboxyl, carbonyl, carbamoyl, carboxamide, or phosphonate, and R11 is alkyl, alkoxy, alkenyl, alkynyl, alkylene, alkenylene, alkenyloxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfonyl, sulfinyl, sulfenyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, =0, =S, phosphonate, carboxyl, carbonyl, carbamoyl, carboxamide, or ureido. The invention also relates to formulations, dosage forms and compositions comprising the salts, and methods of using the salts, formulations, dosage forms and compositions.

公开(公告)号：EP2015750A2

公开(公告)日：2009-01-21

申请号：EP07756162.9

申请日：2007-04-27

申请人： Northwestern University

发明人： WATTERSON, Martin ,  VAN ELDIK, Linda ,  HU, Wenhui

IPC分类号： A61K31/501 ,  A61K31/50 ,  A61P25/28 ,  A61K31/435

CPC分类号： A61K31/50 ,  A61K31/435 ,  A61K31/501 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

公开(公告)号：EP1812007A2

公开(公告)日：2007-08-01

申请号：EP05823123.4

申请日：2005-11-02

申请人： Northwestern University ,  Université Louis Pasteur de Strasbourg

发明人： WATTERSON, D. Martin ,  VAN ELDIK, Linda ,  HAIECH, Jacques ,  HIBERT, Marcel ,  BOURGUIGNON, Jean-jacques ,  VELENTZA, Anastasia ,  HU, Wenhui ,  ZASADZKI, Magdelena

IPC分类号： A61K31/535 ,  C07D413/00 ,  A61K31/50 ,  C07D487/00 ,  A61K31/495 ,  C07D237/26 ,  A01N43/58 ,  C07D237/36 ,  A01N43/60

CPC分类号： C07D403/12 ,  C07D237/36 ,  C07D401/12 ,  C07D401/14 ,  C07D498/06

摘要： The invention relates to novel chemical compounds of Formula I compositions and methods of using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.