公开(公告)号：EP2516148A1

公开(公告)日：2012-10-31

申请号：EP10807630.8

申请日：2010-12-20

申请人： SOPREMA (Société par Actions Simplifiée Unipersonnelle) ,  Universite De Strasbourg (Etablissement Public à Caractère Scientifique, Culturel et Professionel)

发明人： BINDSCHEDLER, Pierre, Etienne ,  PERRIN, Rémi ,  HABLOT, Elodie ,  ROBACH, Christine ,  AVEROUS, Luc ,  BOUQUEY, Michel

IPC分类号： B32B5/00 ,  D06N3/00 ,  E04D5/02

CPC分类号： E04D5/06 ,  B29K2075/00 ,  B29K2077/00 ,  B32B27/12 ,  B32B27/34 ,  B32B27/40 ,  B32B2262/04 ,  B32B2262/06 ,  B32B2262/062 ,  B32B2262/065 ,  B32B2307/7246 ,  B32B2307/7265 ,  B32B2307/73 ,  B32B2419/00 ,  B32B2419/06 ,  D06M15/564 ,  D06M15/693 ,  D06M2200/11 ,  D06M2200/12 ,  D06N5/00 ,  D06N2201/04 ,  D06N2201/042 ,  D06N2201/045 ,  D06N2209/125 ,  D06N2209/128 ,  D06N2209/142 ,  D06N2209/143

摘要： The present invention relates to a flexible sealing membrane that is particularly useful for covering roofs. The flexible sealing membrane is usable for sealing substantially planar surfaces such as roofs or the like, said membrane being essentially water- and steam-tight, characterized in that said membrane does not contain any bitumen or bitumen derivative and also characterized in that said membrane is essentially formed of at least one thermoplastic (co)polyurethane or thermoplastic (co)polyamide, thus ensuring the essentials of said sealing functions, said thermoplastic (co)polyurethane(s) or thermoplastic (co)polyamide(s) each containing at least one natural monomer that is integrated into the (co)polymer during the polymerization(s) thereof.

公开(公告)号：EP2390345A1

公开(公告)日：2011-11-30

申请号：EP11167963.5

申请日：2011-05-27

申请人： Comptoir Agricole ,  Universite De Strasbourg

发明人： Jeltsch, Jean-Marc ,  Phalip, Vincent ,  Duranton, Jérôme ,  Tranier, Marie-Stéphane ,  Misrahi, Audrey ,  Falter, Cédric

IPC分类号： C12P21/00 ,  C07K14/37 ,  C12N9/14 ,  C12N9/42 ,  C12N1/14 ,  C12R1/77 ,  C12R1/685

CPC分类号： C12P21/00 ,  C12N1/14 ,  C12N9/248 ,  D21H17/005

摘要： Procédé de préparation de molécules d'intérêt par fermentation d'un substrat en phase solide.

摘要翻译： 通过固相底物的发酵制备感兴趣的分子包括：提供底物; 潜在地减小基材的尺寸; 对基材进行消毒干燥; 在搅拌下用悬浮液中的微生物孵育底物; 在反应器中以固态发酵底物; 对发酵的基质进行灭菌; 通过体积为底物质量的0.5-5倍的水回收底物; 收集洗涤液; 从液体中提取目标分子; 并任选地干燥感兴趣的分子。 通过发酵固相底物制备感兴趣的分子包括：（a）提供底物; （b）潜在地减小基材的尺寸，以获得平均直径小于1mm的100％的颗粒; （c）将基材消毒干燥; （d）在搅拌下用悬浮液中的微生物以1×10 5> 1×10 7个孢子/ g底物，优选2.5×10 5个孢子/ g底物的速率孵育底物以具有尺寸（aw） 为0.950-0.999μm，优选为0.980-0.995μm; （e）在反应器中以固体状态发酵底物，在大气压下，在18-30℃的温度下搅拌2-8天，优选3-6天; （f）对发酵的基质进行灭菌; （g）用底物质量的0.5-5倍的体积的水回收底物; （h）收集洗涤液; （i）从步骤（h）中收集的液体提取目的分子; 和（j）干燥感兴趣的分子。

公开(公告)号：EP2313401A2

公开(公告)日：2011-04-27

申请号：EP09784508.5

申请日：2009-07-10

申请人： Centre National de la Recherche Scientifique (C.N.R.S) ,  Universite De Strasbourg

发明人： BARILLON, Rémi ,  BOUAJILA, Ezeddine ,  DOUCE, Laurent ,  JUNG, Jean-Marc ,  STUTTGE, Louise

IPC分类号： C07D413/10 ,  C07D263/32 ,  C07D233/64 ,  G01T1/02

CPC分类号： C07D413/10

摘要： The invention relates to a novel discriminating molecule family for neutron and gamma radiation and to the preparation method thereof. Said molecules are also useful for detecting radiation (X, gamma, electrons, protons, ions), and thus for manufacturing radar and industrial or medical dosimetry instruments.

公开(公告)号：EP2254880A2

公开(公告)日：2010-12-01

申请号：EP09713314.4

申请日：2009-02-23

申请人： Nexgenix Pharmaceuticals ,  Universite De Strasbourg

发明人： HECK, James ,  WINSSINGER, Nicolas ,  CHABALA, John C. ,  BARLUENGA, Sofia ,  CHEN, Ruihong ,  RUBENSTEIN, Allan ,  YU, Jin-Chen

IPC分类号： C07D313/00 ,  C07D315/00 ,  A61K31/365

CPC分类号： C07D313/00

摘要： The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.

公开(公告)号：EP2214813A2

公开(公告)日：2010-08-11

申请号：EP08872202.0

申请日：2008-11-26

申请人： CNRS Centre National De La Recherche Scientifique ,  Universite De Strasbourg

发明人： PHAM-HUU, Cuong ,  KELLER, Nicolas ,  LEDOUX, Marc, Jacques ,  JANOWSKA, Izabella ,  EDOUARD, David ,  KELLER-SPITZER, Valérie ,  ROMERO, Thierry ,  YU, Liu

IPC分类号： B01J19/00 ,  B01J20/28 ,  B01J35/06 ,  B01J35/10 ,  B01J20/20

CPC分类号： B01J19/0093 ,  B01J21/063 ,  B01J21/08 ,  B01J21/185 ,  B01J23/755 ,  B01J29/40 ,  B01J2219/00846 ,  B82Y30/00 ,  C01B32/50

摘要： The invention relates to a chemical reactor having a nanometric structure and including at least one member in which is formed at least one reaction chamber, said chamber being at least partially filled with a high specific-surface material having a specific surface higher than 5 m
2 /g, characterised in that said high specific-surface material is selected from nanotubes or nanofibres. The nanotubes or nanofibres are preferably selected in the group comprising β-SiC nanotubes or nanofibres and TiO
2 nanotubes or nanofibres. They can be deposited on an intermediate structure selected in the group comprising glass fibres, carbon fibres, SiC foams, carbon foams, cellular β-SiC foams, said intermediate structure at least partially filling the reaction chamber of the reactor.

公开(公告)号：EP4032560A1

公开(公告)日：2022-07-27

申请号：EP21153325.2

申请日：2021-01-25

申请人： Centre National pour la Recherche Scientifique ,  UNIVERSITE DE STRASBOURG ,  Les Hôpitaux Universitaires de Genève ,  UNIVERSITE DE GENEVE

发明人： DECHER, Gero ,  WALPOTH, Beat ,  FONTANA, Pierre ,  WITT, Maria ,  DE VALENCE, Sarra ,  TSCHOPP, Michel ,  FELIX, Olivier

IPC分类号： A61L27/18 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L33/00

摘要： The present invention is directed to materials compatible with blood, implantable devices comprising said material, methods of preparation of such material and medical devices coated therewith and uses thereof for anti-thrombotic and/or cell-proliferating aspects.

公开(公告)号：EP2349966A1

公开(公告)日：2011-08-03

申请号：EP09783770.2

申请日：2009-10-06

申请人： Assistance Publique - Hôpitaux de Paris ,  Université Pierre et Marie Curie ,  Universite De Strasbourg

发明人： CHOPPIN, Sabine ,  COLOBERT, Françoise ,  HANQUET, Gilles ,  LEROUX, Frédéric ,  MAHMOUDI, Nassira ,  MAZIER, Dominique

IPC分类号： C07C41/01 ,  C07C43/23

CPC分类号： C07C43/23 ,  C07B2200/07 ,  C07C41/26 ,  C07D317/54

摘要： The present invention discloses new analogs of polysphorin and their uses as antimalarial drugs which are highly effective in the hepatic phase of the disease. The present invention further discloses a new method for preparing these compounds.

公开(公告)号：EP2242359A1

公开(公告)日：2010-10-27

申请号：EP09702521.7

申请日：2009-01-15

申请人： Universite De Strasbourg ,  WINSSINGER, Nicolas ,  BARLUENGA, Sofia ,  KARPLUS, Martin

发明人： WINSSINGER, Nicolas ,  BARLUENGA, Sofia ,  KARPLUS, Martin

IPC分类号： A01N31/14 ,  A61K31/02

CPC分类号： C07D313/00 ,  A61K31/335 ,  A61K31/365 ,  A61K31/4025 ,  A61K31/435 ,  A61K31/4453 ,  A61K31/4523 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07D211/14 ,  C07D225/06 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

摘要： Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

公开(公告)号：EP2185565A2

公开(公告)日：2010-05-19

申请号：EP08805961.3

申请日：2008-06-09

申请人： BIOMERIEUX ,  CNRS ,  Universite De Strasbourg

发明人： LAURENT, Alain ,  LAAYOUN, Ali ,  KOTERA, Mitsuharu

IPC分类号： C07D495/04 ,  G01N33/58 ,  C07D333/24 ,  C07D233/32 ,  C07C245/14 ,  C12Q1/68

CPC分类号： C07D495/04 ,  Y10T436/13

摘要： The invention relates to at least one marking reagent of the formula (1) in which: R1 is at least one detectable marker; L and A are each a bonding arm; n is an integer equal to 1; and u is an integer between 0 and 2. The invention also relates to a method for the synthesis of said markers and to applications for marking biological cells, in particular nucleic acids, with a marking reagent bearing diazo and nitro functions. The invention can preferably be used in the field of diagnosis.

公开(公告)号：EP2124709A1

公开(公告)日：2009-12-02

申请号：EP08762153.8

申请日：2008-02-25

申请人： Universite De Strasbourg (Etablissement Public à Caractère Scientifique, Culturel et Professionel) ,  Centre National de la Recherche Scientifique (Etablissement Public à Caractère Scientifique, et Technologique)

发明人： DE MATHELIN, Michel ,  GANGLOFF, Jacques ,  ZANNE, Philippe ,  OTT, Laurent

IPC分类号： A61B1/05

CPC分类号： A61B1/05 ,  A61B1/00147 ,  A61B1/0051

摘要： The invention relates to a flexible endoscope device comprising an elongated flexible body having an end segment bearing or defining the endoscope head, and provided with an optical system and that can be curved or bent in at least two mutually perpendicular directions, said elongated body being functionally connected at the other end thereof to a control means capable of controlling at least the movements and/or the arrangement of said end segment. The device (1) is characterised in that it further comprises automatic flexion and positioning means of the end segment (3) by visual control, said means essentially comprising a video processing means (6) for receiving the images or video signals provided by the optical system (4) of the endoscope head (3') using a computer means (7) capable of carrying out visual control operations on the basis of the processed video signals and of transmitting control signals, and actuation means (8, 8') that are part of or associated with the control means (6) capable of controlling the end segment (3) and receiving the control signals supplied by the computer means (7).