公开(公告)号：EP2250152A1

公开(公告)日：2010-11-17

申请号：EP09715302.7

申请日：2009-02-26

申请人： Novartis AG

发明人： AMSTUTZ, René ,  BOLD, Guido ,  COTESTA, Simona ,  JAHNKE, Wolfgang ,  MARZINZIK, Andreas ,  MUELLER-HARTWIEG, Constanze ,  OFNER, Silvio ,  STAUFFER, Frédéric ,  ZIMMERMANN, Johann

IPC分类号： C07D215/48 ,  C07D401/04 ,  C07F9/60 ,  C07D215/18 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12 ,  A61K31/675 ,  A61P35/04

CPC分类号： C07D215/48 ,  C07D215/18 ,  C07D401/04 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12 ,  C07F9/60 ,  C07F9/65583 ,  C07F9/65586

摘要： The invention relates to a compound of formula (I) wherein the substituents are as described in the specification, which are useful as farnesyl pyrophosphate synthase modulators, e.g. in the treatment of proliferative diseases, to methods of manufacturing such compounds and to intermediates thereof.