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公开(公告)号:EP2427490A1
公开(公告)日:2012-03-14
申请号:EP10719858.2
申请日:2010-05-06
申请人: Novartis AG
发明人: BRAENDLE, Edgar , RAE, Patricia , RANGWALA, Shamina M. , STOVER, David Raymond , TAYLOR, Ann
IPC分类号: C07K16/18 , A61P35/00 , A61P3/10
CPC分类号: C07K16/18 , A61K38/19 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf -1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted as "DKK1/4") are provided.