公开(公告)号：EP2004693B1

公开(公告)日：2012-06-06

申请号：EP07754114.2

申请日：2007-03-29

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： STOVER, David Raymond ,  PRASSLER, Josef ,  BERGER, Catrin ,  BROCKS, Bodo

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P29/00 ,  G01N33/00 ,  C12N15/13 ,  C12N15/85 ,  A61K47/48 ,  A61K38/00 ,  A61K31/00

CPC分类号： C07K16/2863 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S435/81

摘要： Antibodies and fragments that bind to the protein target c Met, particularly to epitopes located in the c Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c Met-related condition such as a cancer, a metastasis, or an inflammatory condition.

公开(公告)号：EP2534176A1

公开(公告)日：2012-12-19

申请号：EP11702650.0

申请日：2011-02-10

申请人： Novartis AG ,  Ablynx N.V.

发明人： CROMIE, Karen ,  DOMBRECHT, Bruno ,  ETTENBERG, Seth ,  KOLKMAN, Joost ,  LI, Jing ,  MEERSCHAERT, Kris ,  STOVER, David Raymond ,  ZHANG, Jingxin

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2316/95 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76

摘要： The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also “DR5”), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as “NB agents”) and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.

摘要翻译： 本发明涉及针对TRAIL细胞表面受体2（本文还称为“DR5”）以及编码它们的化合物或构建体，特别是编码它们的蛋白质和多肽和核苷酸的氨基酸序列（本文中称为“ 其整体为“NB剂”）及其片段及其药学上有效的变体，以及它们在诊断和治疗DR5相关疾病和病症中的用途。

公开(公告)号：EP2004693A2

公开(公告)日：2008-12-24

申请号：EP07754114.2

申请日：2007-03-29

申请人： NOVARTIS AG ,  Novartis Pharma GmbH

发明人： STOVER, David Raymond ,  PRASSLER, Josef ,  BERGER, Catrin ,  BROCKS, Bodo

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P29/00 ,  G01N33/00 ,  C12N15/13 ,  C12N15/85 ,  A61K47/48 ,  A61K38/00 ,  A61K31/00

CPC分类号： C07K16/2863 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S435/81

摘要： Antibodies and fragments that bind to the protein target c Met, particularly to epitopes located in the c Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c Met-related condition such as a cancer, a metastasis, or an inflammatory condition.

公开(公告)号：EP2427490A1

公开(公告)日：2012-03-14

申请号：EP10719858.2

申请日：2010-05-06

申请人： Novartis AG

发明人： BRAENDLE, Edgar ,  RAE, Patricia ,  RANGWALA, Shamina M. ,  STOVER, David Raymond ,  TAYLOR, Ann

IPC分类号： C07K16/18 ,  A61P35/00 ,  A61P3/10

CPC分类号： C07K16/18 ,  A61K38/19 ,  A61K39/39533 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf -1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted as "DKK1/4") are provided.