公开(公告)号：EP2113030A2

公开(公告)日：2009-11-04

申请号：EP08709005.6

申请日：2008-02-14

申请人： Novartis AG

发明人： CHEN, Jian ,  GARZA, Dan ,  LI, Hao ,  STEVENSON, Susan C. ,  WU, Zhidan

IPC分类号： C12N15/12 ,  C07K14/435 ,  C12Q1/68 ,  G01N33/50 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713

CPC分类号： G01N33/5079 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/12 ,  C12N2330/31 ,  G01N2800/52

摘要： The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate conditions associated with mitochondrial dysfunction. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with mitochondrial dysfunction.