公开(公告)号：EP2124819A2

公开(公告)日：2009-12-02

申请号：EP08717398.5

申请日：2008-03-05

申请人： Novartis AG

发明人： MÜLLER, Achim ,  KNUTH, Monika ,  SCHMID, Katharina ,  PASTERNACK, Ralf ,  ZOTZEL, Jens ,  OERTEL, Kai ,  REIFF, Christine ,  FUCHSBAUER, Hans-Lothar

IPC分类号： A61F2/14 ,  A61L27/22 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  G02B1/04

CPC分类号： C08J7/047 ,  A61F2/14 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  C08J2489/00 ,  G02C7/04 ,  C08L89/00

摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

公开(公告)号：EP2124819B1

公开(公告)日：2012-02-08

申请号：EP08717398.5

申请日：2008-03-05

申请人： Novartis AG

发明人： MÜLLER, Achim ,  KNUTH, Monika ,  NIKOLAUS, Katharina ,  PASTERNACK, Ralf ,  ZOTZEL, Jens ,  OERTEL, Kai ,  REIFF, Christine ,  FUCHSBAUER, Hans-Lothar

IPC分类号： A61F2/14 ,  A61L27/22 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  G02B1/04

CPC分类号： C08J7/047 ,  A61F2/14 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  C08J2489/00 ,  G02C7/04 ,  C08L89/00

摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.

摘要翻译： 本发明涉及一种制备复合材料的方法，其包括以下步骤：（a）提供疏水性有机体材料，和（b）通过首先将非亲水性表面涂层非共价连接到疏水性有机大块材料上 本体材料的表面是包含疏水部分的水溶性肽; 然后化学或酶促交联水溶性肽。 根据本发明的方法制造的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此特别适用于眼科装置。