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1.发明公开NOVEL ESTROGEN RECEPTOR LIGAND BINDING DOMAIN VARIANTS AND NOVEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS 有权NEW雌激素受体配体结合结构域变异和新的配体和药物组合物
公开(公告)号：EP1397382A2
公开(公告)日：2004-03-17
申请号：EP02731968.0
申请日：2002-05-31
申请人： Novartis AG
发明人： BRACKEN, Kathryn Rene , DE LOS ANGELES, Joseph, E. , HUANG, Ying , KADAN, Michael, J. , KSANDER, Gary, M. , ZERBY, Dennis, B.
IPC分类号： C07K14/435 , C12N5/10 , C12N15/11 , C12N15/63
CPC分类号： C07K14/4705 , C07K2319/00
摘要： Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective 'molecular gene switches' is disclosed. Methods of regulating gene function using these switches are provided.
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2.发明授权NOVEL ESTROGEN RECEPTOR LIGAND BINDING DOMAIN VARIANTS AND NOVEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS 有权NEW雌激素受体配体结合结构域变异和新的配体和药物组合物
公开(公告)号：EP1397382B1
公开(公告)日：2008-08-06
申请号：EP02731968.0
申请日：2002-05-31
申请人： Novartis AG
发明人： BRACKEN, Kathryn Rene , DE LOS ANGELES, Joseph, E. , HUANG, Ying , KADAN, Michael, J. , KSANDER, Gary, M. , ZERBY, Dennis, B.
IPC分类号： C07K14/435 , C12N5/10 , C12N15/11 , C12N15/63
CPC分类号： C07K14/4705 , C07K2319/00
摘要： Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective 'molecular gene switches' is disclosed. Methods of regulating gene function using these switches are provided.
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