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1.BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权
标题翻译: 双环HETEROFLEXIBLE周期衍生物用于治疗肺动脉高压公开(公告)号:EP2751108B1
公开(公告)日:2016-04-27
申请号:EP12772493.8
申请日:2012-08-31
申请人: Novartis AG
发明人: BRUCE, Ian , CHAMOIN, Sylvie , COLLINGWOOD, Stephen Paul , FURET, Pascal , FURMINGER, Vikki , LEWIS, Sarah , LOREN, Jon Christopher , MOLTENI, Valentina , SAUNDERS, Alex Michael , SHAW, Duncan , SVIRIDENKO, Lilya , THOMSON, Christopher , YEH, Vince , JANUS, Diana , WEST, Ryan
IPC分类号: C07D471/04 , A61K31/4162 , A61K31/4188 , A61P9/12
CPC分类号: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
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公开(公告)号:EP4340808A1
公开(公告)日:2024-03-27
申请号:EP22727444.6
申请日:2022-05-18
申请人: Novartis AG
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公开(公告)号:EP4065228A1
公开(公告)日:2022-10-05
申请号:EP20817082.9
申请日:2020-11-23
申请人: Novartis AG
发明人: BOSS, Kelly D. , FAN, Yi , FLYER, Alec Nathanson , HARDY, Declan , HUANG, Zhihong , LINKENS, Kathryn Taylor , LOREN, Jon Christopher , MA, Fupeng , MOLTENI, Valentina , SHAW, Duncan , SMITH, Jeffrey , SOLOVAY, Catherine Fooks
IPC分类号: A61P27/00 , C07D413/06 , A61K31/42
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4.BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权
标题翻译: 双环HETEROFLEXIBLE周期衍生物用于治疗肺动脉高压公开(公告)号:EP2751108A1
公开(公告)日:2014-07-09
申请号:EP12772493.8
申请日:2012-08-31
申请人: Novartis AG , IRM LLC
发明人: BRUCE, Ian , CHAMOIN, Sylvie , COLLINGWOOD, Stephen Paul , FURET, Pascal , FURMINGER, Vikki , LEWIS, Sarah , LOREN, Jon Christopher , MOLTENI, Valentina , SAUNDERS, Alex Michael , SHAW, Duncan , SVIRIDENKO, Lilya , THOMSON, Christopher , YEH, Vince , JANUS, Diana , WEST, Ryan
IPC分类号: C07D471/04 , A61K31/4162 , A61K31/4188 , A61P9/12
CPC分类号: C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要: Bicyclic heterocyclic derivatives of formula (I) useful in inhibiting PDGF receptor mediated biological activity. Wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
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