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1.发明公开BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权双环HETEROFLEXIBLE周期衍生物用于治疗肺动脉高压
公开(公告)号：EP2751108A1
公开(公告)日：2014-07-09
申请号：EP12772493.8
申请日：2012-08-31
申请人： Novartis AG , IRM LLC
发明人： BRUCE, Ian , CHAMOIN, Sylvie , COLLINGWOOD, Stephen Paul , FURET, Pascal , FURMINGER, Vikki , LEWIS, Sarah , LOREN, Jon Christopher , MOLTENI, Valentina , SAUNDERS, Alex Michael , SHAW, Duncan , SVIRIDENKO, Lilya , THOMSON, Christopher , YEH, Vince , JANUS, Diana , WEST, Ryan
IPC分类号： C07D471/04 , A61K31/4162 , A61K31/4188 , A61P9/12
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula (I) useful in inhibiting PDGF receptor mediated biological activity. Wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
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2.发明授权IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS 有权AS ALK-缝边SUITABLE咪唑并[1,2-A] -PYRIDINDERIVATE
公开(公告)号：EP2212323B1
公开(公告)日：2012-08-15
申请号：EP08838625.5
申请日：2008-10-15
申请人： Novartis AG
发明人： SHAW, Duncan , LEBLANC, Catherine , LIZOS, Dimitrios , RITCHIE, Cathy , FURMINGER, Vikki , LEWIS, Sarah , HORNSPERGER, Benoit , STIEFL, Nikolaus, Johannes , WEILER, Sven
IPC分类号： C07D471/04 , A61K31/437 , A61P11/00 , A61P19/00
CPC分类号： C07D471/04
摘要： Compounds of formula I: in free or salt or solvate form, where R1, R2, R3 and R20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.
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3.发明授权BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权双环HETEROFLEXIBLE周期衍生物用于治疗肺动脉高压
公开(公告)号：EP2751108B1
公开(公告)日：2016-04-27
申请号：EP12772493.8
申请日：2012-08-31
申请人： Novartis AG
发明人： BRUCE, Ian , CHAMOIN, Sylvie , COLLINGWOOD, Stephen Paul , FURET, Pascal , FURMINGER, Vikki , LEWIS, Sarah , LOREN, Jon Christopher , MOLTENI, Valentina , SAUNDERS, Alex Michael , SHAW, Duncan , SVIRIDENKO, Lilya , THOMSON, Christopher , YEH, Vince , JANUS, Diana , WEST, Ryan
IPC分类号： C07D471/04 , A61K31/4162 , A61K31/4188 , A61P9/12
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
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4.发明公开
公开(公告)号：EP2212323A2
公开(公告)日：2010-08-04
申请号：EP08838625.5
申请日：2008-10-15
申请人： Novartis AG
发明人： SHAW, Duncan , LEBLANC, Catherine , LIZOS, Dimitrios , RITCHIE, Cathy , FURMINGER, Vikki , LEWIS, Sarah , HORNSPERGER, Benoit , STIEFL, Nikolaus, Johannes , WEILER, Sven
IPC分类号： C07D471/04 , A61K31/437 , A61P11/00 , A61P19/00
CPC分类号： C07D471/04
摘要： Compounds of formula I: in free or salt or solvate form, where R1, R2, R3 and R20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.
摘要翻译： 式I化合物：游离形式或盐或溶剂合物形式（其中R 1，R 2，R 3和R 20具有说明书中指出的含义）可用于治疗由ALK-5和/或ALK-4受体介导的疾病。 还描述了含有用于制备该化合物的化合物和方法的药物组合物。 这些化合物可用于治疗炎性或阻塞性气道疾病，如肺高血压，肺纤维化，肝纤维化，癌症，肌肉疾病如肌萎缩和肌肉营养不良，以及系统性骨骼疾病如骨质疏松症。
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