公开(公告)号：EP1896447A2

公开(公告)日：2008-03-12

申请号：EP06754340.5

申请日：2006-06-13

申请人： Novartis AG

发明人： SALTER, Rhys ,  RODRIGUEZ PEREZ, Maria Ines ,  MOENIUS, Thomas ,  VOGES, Rolf ,  ANDRES, Hendrik ,  BORDEAUX, Kirk

IPC分类号： C07D401/04 ,  C07D295/155

CPC分类号： C07D295/155 ,  C07D401/04

摘要： The invention relates to new processes for the manufacture of N-{5-[4-(4-methyl-piperazino- methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine of formula (I), new processes for the manufacture of metabolites of N-{5-[4-(4-methyl-piperazino-methyl)- benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine observed after administration of the compound to warm-blooded animals as well as to intermediates used in said processes. New starting materials as well as processes for the preparation thereof are likewise the subject of this invention. The processes described herein are especially suitable to furnish said compounds having isotopic labeling. The such obtained labeled compounds are in particular suitable to track and to investigate into the metabolism of N-{5-[4-(4-methyl- piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and its pharmaceutically acceptable salts in clinical and pre-clinical studies.