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    ORGANIC COMPOUNDS
    2.
    发明公开
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：EP2155721A1

    公开(公告)日：2010-02-24

    申请号：EP08759419.8

    申请日：2008-05-05

    申请人： Novartis AG

    发明人： FAIRHURST, Robin Alec ,  BUTLER, Rebecca ,  OAKLEY, Paul ,  COLLINGWOOD, Stephen Paul ,  SMITH, Nichola ,  STANLEY, Emily ,  RODRIGUEZ PEREZ, Maria Ines

    IPC分类号： C07D401/14 ,  A61K31/497 ,  A61P11/00 ,  A61P29/00

    CPC分类号： C07D401/14

    摘要： A compound of formula (I), or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 and R5a are as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration.

    摘要翻译： 其中M 1，M 2，L 1，L 2，W 1，W 2，X 1，X 2，Y 1，Y 2，A，R 5和R 5a是（I）化合物或其互变异构体或立体异构体或溶剂化物或药学上可接受的盐， 如本文所定义，用于治疗可通过阻断上皮钠通道治疗的病症，特别是受益于粘膜水合作用的病症。

    METHODS AND INTERMEDIATES FOR THE PREPARATION OF OPTIONALLY RADIO-LABELED IMATINIB
    3.
    发明公开
    METHODS AND INTERMEDIATES FOR THE PREPARATION OF OPTIONALLY RADIO-LABELED IMATINIB 审中-公开
    过程和中间产品用于可选FUNKETIKETTIERTEM伊马替尼生产

    公开(公告)号：EP1896447A2

    公开(公告)日：2008-03-12

    申请号：EP06754340.5

    申请日：2006-06-13

    申请人： Novartis AG

    发明人： SALTER, Rhys ,  RODRIGUEZ PEREZ, Maria Ines ,  MOENIUS, Thomas ,  VOGES, Rolf ,  ANDRES, Hendrik ,  BORDEAUX, Kirk

    IPC分类号： C07D401/04 ,  C07D295/155

    CPC分类号： C07D295/155 ,  C07D401/04

    摘要： The invention relates to new processes for the manufacture of N-{5-[4-(4-methyl-piperazino- methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine of formula (I), new processes for the manufacture of metabolites of N-{5-[4-(4-methyl-piperazino-methyl)- benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine observed after administration of the compound to warm-blooded animals as well as to intermediates used in said processes. New starting materials as well as processes for the preparation thereof are likewise the subject of this invention. The processes described herein are especially suitable to furnish said compounds having isotopic labeling. The such obtained labeled compounds are in particular suitable to track and to investigate into the metabolism of N-{5-[4-(4-methyl- piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and its pharmaceutically acceptable salts in clinical and pre-clinical studies.