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公开(公告)号:EP2051990B1
公开(公告)日:2013-02-06
申请号:EP07813569.6
申请日:2007-07-31
申请人: Novartis AG
发明人: CHAREST, Mark G. , CHEN, Christine Hiu-Tung , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , PHAM, Ly Luu , SHARMA, Sushil Kumar , STRAUB, Christopher Sean , WANG, Run-Ming David , YANG, Fan , ZAWEL, Leigh
IPC分类号: C07K5/06 , A61P35/00 , A61K31/4439 , A61K31/427
CPC分类号: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
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公开(公告)号:EP2051990A1
公开(公告)日:2009-04-29
申请号:EP07813569.6
申请日:2007-07-31
申请人: NOVARTIS AG , Novartis Pharma GmbH
发明人: CHAREST, Mark G. , CHEN, Christine Hiu-Tung , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , PHAM, Ly Luu , SHARMA, Sushil Kumar , STRAUB, Christopher Sean , WANG, Run-Ming David , YANG, Fan , ZAWEL, Leigh
IPC分类号: C07K5/06 , A61P35/00 , A61K31/4439 , A61K31/427
CPC分类号: C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要: The present invention is directed to a compound of the formula (I); or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
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公开(公告)号:EP1870399A1
公开(公告)日:2007-12-26
申请号:EP07115019.7
申请日:2001-08-30
申请人: Novartis AG , NOVARTIS-PHARMA GMBH
发明人: BAIR, Kenneth Walter , GREEN, Michael A. , PEREZ, Lawrence Blas , REMISZEWSKI, Stacy William , SAMBUCETTI, Lidia , VERSACE, Richard William , SHARMA, Sushil Kumar
IPC分类号: C07D209/16 , C07C259/06 , C07D417/12 , C07D403/12 , C07D471/04 , C07D519/00 , C07D295/02 , A61K31/4045 , A61K31/16 , A61P35/00
CPC分类号: C07D401/12 , C04B35/632 , C07C259/06 , C07D209/16 , C07D233/64 , C07D295/155 , C07D307/81 , C07D403/12 , C07D405/12 , C07D471/04
摘要: The present invention provides hydroxamate compounds of formula I:
which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.摘要翻译: 本发明提供式I的异羟肟酸酯化合物:它们是脱乙酰酶抑制剂。 该化合物适用于具有抗增殖性质的药物组合物。
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