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    IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS
    3.
    发明公开
    IMIDAZO [1,2-A] PYRIDINE DERIVATIVES USEFUL AS ALK INHIBITORS 有权
    IMIDAZO [1,2-A]吡啶衍生物可用作ALK抑制剂

    公开(公告)号：EP2212323A2

    公开(公告)日：2010-08-04

    申请号：EP08838625.5

    申请日：2008-10-15

    申请人： Novartis AG

    发明人： SHAW, Duncan ,  LEBLANC, Catherine ,  LIZOS, Dimitrios ,  RITCHIE, Cathy ,  FURMINGER, Vikki ,  LEWIS, Sarah ,  HORNSPERGER, Benoit ,  STIEFL, Nikolaus, Johannes ,  WEILER, Sven

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P11/00 ,  A61P19/00

    CPC分类号： C07D471/04

    摘要： Compounds of formula I: in free or salt or solvate form, where R1, R2, R3 and R20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.

    摘要翻译： 式I化合物：游离形式或盐或溶剂合物形式（其中R 1，R 2，R 3和R 20具有说明书中指出的含义）可用于治疗由ALK-5和/或ALK-4受体介导的疾病。 还描述了含有用于制备该化合物的化合物和方法的药物组合物。 这些化合物可用于治疗炎性或阻塞性气道疾病，如肺高血压，肺纤维化，肝纤维化，癌症，肌肉疾病如肌萎缩和肌肉营养不良，以及系统性骨骼疾病如骨质疏松症。