公开(公告)号：EP2464649A1

公开(公告)日：2012-06-20

申请号：EP10744553.8

申请日：2010-08-10

申请人： Novartis AG

发明人： FU, Xingnian ,  HE, Feng ,  LI, Yue ,  LIU, Lei ,  MI, Yuan ,  XU, Yao-chang ,  XUN, Guoliang ,  YU, Zhengtian ,  ZHANG, Ji Yue (Jeff) ,  DAI, Miao

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D487/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

公开(公告)号：EP2755976A1

公开(公告)日：2014-07-23

申请号：EP12769172.3

申请日：2012-09-13

申请人： Novartis AG

发明人： CHEN, Chao ,  DENG, Haibing ,  GUO, Haibing ,  HE, Feng ,  JIANG, Lei ,  LIANG, Fang ,  MI, Yuan ,  WAN, Huixin ,  XU, Yao-Chang ,  YU, Hongping ,  ZHANG, Ji Yue (Jeff)

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/437 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K31/551 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D471/04 ,  C07D491/107 ,  C07D519/00

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

公开(公告)号：EP3472166A1

公开(公告)日：2019-04-24

申请号：EP17733536.1

申请日：2017-06-09

申请人： Novartis AG

发明人： CHAN, Ho Man ,  FU, Xingnian ,  GU, Xiang-Ju Justin ,  HUANG, Ying ,  LI, Ling ,  MI, Yuan ,  QI, Wei ,  SENDZIK, Martin ,  SUN, Yongfeng ,  WANG, Long ,  YU, Zhengtian ,  ZHANG, Hailong ,  ZHANG, Ji Yue (Jeff) ,  ZHANG, Man ,  ZHANG, Qiong ,  ZHAO, Kehao

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/02

公开(公告)号：EP4034535A1

公开(公告)日：2022-08-03

申请号：EP20868772.3

申请日：2020-09-24

申请人： Novartis AG

发明人： DAI, Xuan ,  DORE, Michael ,  GU, Xiang-Ju Justin ,  LIU, Kevin Kun Chin ,  MAK, Sing Yeung Frankie ,  MI, Yuan ,  OYANG, Counde ,  PAPILLON, Julien ,  QI, Wei (Vicky) ,  YAN, Xiaoxia ,  YU, Zhengtian ,  ZHANG, Ji Yue (Jeff) ,  ZHAO, Kehao ,  LI, Ling

IPC分类号： C07D403/14 ,  C07D401/14 ,  A61P35/00 ,  A61K31/505 ,  A61K31/435

公开(公告)号：EP2755976B1

公开(公告)日：2018-07-18

申请号：EP12769172.3

申请日：2012-09-13

申请人： Novartis AG

发明人： CHEN, Chao ,  DENG, Haibing ,  GUO, Haibing ,  HE, Feng ,  JIANG, Lei ,  LIANG, Fang ,  MI, Yuan ,  WAN, Huixin ,  XU, Yao-Chang ,  YU, Hongping ,  ZHANG, Ji Yue (Jeff)

IPC分类号： A61K45/06 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  C07D491/107 ,  C07D471/04 ,  C07D519/00 ,  A61K31/437

CPC分类号： A61K31/551 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D471/04 ,  C07D491/107 ,  C07D519/00

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

公开(公告)号：EP2673277A1

公开(公告)日：2013-12-18

申请号：EP12704039.2

申请日：2012-02-08

申请人： Novartis AG

发明人： DENG, Haibing ,  FU, Xingnian ,  GUO, Haibing ,  HE, Feng ,  MI, Yuan ,  YAN, Xiaoxia ,  YU, Hongping ,  ZHANG, Ji Yue (Jeff)

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/5025 ,  A61K31/5377 ,  A61K45/06 ,  C07D487/04

摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).