公开(公告)号：EP2337582A1

公开(公告)日：2011-06-29

申请号：EP09793230.5

申请日：2009-10-01

申请人： Novartis AG ,  Cornell University

发明人： RAJU SEETHARAMAN, Gopinath ,  HARLAND, Richard ,  ALBEE II, Lee David ,  PATEL, Mayur Navnitbhai ,  OSTERRIEDER, Nikolaus ,  KAUFER, Benedikt B.

IPC分类号： A61K39/265 ,  A61K39/102 ,  C07K14/05 ,  C12N15/869

CPC分类号： A61K39/102 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55566 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16721 ,  C12N2710/16722 ,  C12N2710/16761

摘要： The disclosure relates generally to the treatment or prevention of disease in cattle. More particularly, the invention is directed to the production and use of modified bovine herpesvirus 1 (BHV-1) and their use in compositions and vaccines that protect cattle from BHV-1 infection while not suppressing the immunological response in the host. In one example, the invention is directed to the use of modified BHV-1, administered with additional immunogens, either through co-administration and/or through administration in combination vaccines, and the use of these vaccines for the protection of cattle from disease. In one example, use of the modified BHV-1 in the administered compositions facilitates an immune response to or against the additional immunogens.