公开(公告)号：EP2985288A4

公开(公告)日：2016-06-08

申请号：EP14804814

申请日：2014-04-30

申请人： PULIKE BIOLOG ENGINEERING INC

发明人： ZHANG XUKE ,  SUN JINZHONG ,  WU RUI ,  TAN FEIFEI ,  BAI CHAOYONG ,  TIAN KEGONG

IPC分类号： C07H21/04 ,  A61K39/245 ,  C07K14/03 ,  C12N7/00 ,  C12N7/04

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/552 ,  C07H21/04 ,  C12N7/00 ,  C12N7/04 ,  C12N2710/16721 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16761 ,  C12N2710/16771

摘要： Provided in the present invention is a vaccine composition comprising an immune amount of attenuated live vaccine, inactivated vaccine, subunit vaccine, synthetic vaccine, or genetically engineered vaccine of the porcine pseudorabies virus strain. The vaccine composition can effectively induce antibody generation, and prevent infections of virulent strains of the porcine pseudorabies virus, and provides effective protection for pigs.

公开(公告)号：EP0736089A1

公开(公告)日：1996-10-09

申请号：EP95904952.0

申请日：1994-12-19

申请人： Merck & Co., Inc.

发明人： PROVOST, Philip J. ,  WADSWORTH, Cathy Warren

IPC分类号： A61K35 ,  A61K39 ,  A61P31 ,  C12N7

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/25 ,  C12N2710/16734 ,  C12N2710/16761 ,  Y10S435/948

摘要： A thermostable varicella zoster virus (tVZV) is useful for the preparation of a vaccine against chickenpox. The tVZV was selected from a population of virus which survived stringent heat inactivation conditions. The surviving virus is used to provide seed virus to produce a new vaccine with enhanced stability.

公开(公告)号：EP2600893A1

公开(公告)日：2013-06-12

申请号：EP11815299.0

申请日：2011-08-04

申请人： Merck Sharp & Dohme Corp.

发明人： KRAH, David L. ,  DEHAVEN, Jill ,  KRISS, Jennifer A. ,  BARR, Colleen M. ,  YAGODICH, Mary

IPC分类号： A61K39/25 ,  A61K39/245 ,  A61K39/275 ,  A61K39/285 ,  C12N7/04

CPC分类号： A61K39/25 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/55 ,  C12N7/00 ,  C12N7/04 ,  C12N13/00 ,  C12N2710/16734 ,  C12N2710/16761

摘要： The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered to a patient. In embodiments of the compositions described herein, the VZV is inactivated with gamma radiation. The invention also provides a method of preparing an inactivated VZV vaccine, the method comprising gamma irradiating a sample comprising a VZV using from about 5 kGy to about 50 kGy of gamma radiation. Also provided by the invention herein is a method of treatment of or immunization against HZ or other disease associated with the reactivation of VZV, the method comprising administering to a subject a vaccine or pharmaceutical composition comprising a therapeutically effective amount of an inactivated VZV and a pharmaceutically acceptable carrier, wherein the VZV is inactivated by gamma irradiation.

公开(公告)号：EP1331270B1

公开(公告)日：2009-01-14

申请号：EP01972708.0

申请日：2001-10-05

申请人： Kyoritsu Seiyaku Corporation

发明人： KAWAKAMI, Kazuo ,  KISHI, Masahiko ,  MOCHIZUKI, Masami

IPC分类号： C12N15/38 ,  C12N7/04 ,  A61K39/245 ,  A61P31/04 ,  A61P31/12 ,  A61P31/22 ,  C07K14/035 ,  C07K14/04 ,  C12N15/869

CPC分类号： C12N7/00 ,  A61K48/00 ,  A61K2039/525 ,  A61K2039/5256 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16622 ,  C12N2710/16722 ,  C12N2710/16743 ,  C12N2710/16761

摘要： An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has at least two types of foreign nucleic acid sequences inserted thereinto, usable as a vector virus or a vaccine. In this attenuated recombinant FHV-1, at least two types of foreign genes are inserted in such a manner as allowing the expression into two different gene regions exerting no lethal effect on the proliferation of the virus in the feline herpesvirus 1 genome.

公开(公告)号：EP1317481A2

公开(公告)日：2003-06-11

申请号：EP01961753.9

申请日：2001-07-27

申请人： Research Corporation Technologies, Inc

发明人： O'CALLAGHAN, Dennis, J.

IPC分类号： C07K14/03 ,  A61K39/245 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/543 ,  C12N7/00 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16761

摘要： This invention relates to mutant Equine herpesvirus type-1 (EHV-1) isolates, and in particular, EHV-1 isolates carrying mutations in the immediate-early (IE) gene of the viral genome. A panel of EHV-1 mutant isolates have been described. Preffered EHV-1 isolates are those which are replication-competent and nonpathogenic. The mutant EHV-1 isolates of the present invention are useful in formulating vaccine compositions for preventing and treating EHV-1 infections in horses. The present invention further provides methods of determining the pathogenicity of an EHV-1 virus present in a horse subject which has been previously immunized with a non-pathogenic EHV-1 isolate of the present invention.

公开(公告)号：EP1155119A1

公开(公告)日：2001-11-21

申请号：EP00904385.2

申请日：2000-01-18

申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

发明人： CHOWDHURY, Shafiqul, I.

IPC分类号： C12N7/01 ,  C12N15/38 ,  A61K39/265 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16743 ,  C12N2710/16761

摘要： A safe live recombinant virus as well as a vaccine is produced by the deletion of a portion of the native glycoprotein E(gE) coding region of bovine herpesvirus 1(BHV-1) followed by the insertion of a plasmid including a foreign functional β-gal at the gE locus. The deletion of gE gene stably attenuates the virus and serves as an immunological marker differentiating vaccinated animals from infected animals. Moreover, production of β-gal allows easy assessment of gEΔ3.1IBRβ virus replication in vaccinated animals and serves as a phenotypic marker which distinguishes it from wild type virus replication in infected animals.

公开(公告)号：EP1129722A1

公开(公告)日：2001-09-05

申请号：EP00103241.6

申请日：2000-02-17

申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH

发明人： Elbers, Knut ,  Seyboldt, Christian ,  Osterrieder, Nikolaus

IPC分类号： A61K39/27 ,  C07K14/03 ,  C12N7/04 ,  C12N15/38

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/27 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16761

摘要： This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.

摘要翻译： 本发明涉及马疱疹病毒（EHV），其中蛋白质gM基本上不存在或被修饰并且相对于其免疫调节能力是非功能的。 本发明的其它方面涉及编码所述病毒的核酸，包含这些病毒或核酸的药物组合物及其用途。 本发明还涉及用于改善针对野生型EHV感染的EHV疫苗诱导的免疫应答的方法，用于预防和治疗EHV感染的方法以及用于区分野生型EHV感染动物与根据本发明的EHV处理的动物的方法。

公开(公告)号：EP0946714A1

公开(公告)日：1999-10-06

申请号：EP97947773.0

申请日：1997-12-10

申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW ,  CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  EQUINE VIROLOGY RESEARCH FOUNDATION

发明人： BROWN, Susanne, Moira ,  SUN, Yi ,  FIELD, Hugh, John

IPC分类号： C12N15 ,  A61K39 ,  A61P31 ,  A61P37 ,  C07K14 ,  C12N7

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/543 ,  A61K2039/552 ,  C07K14/005 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16761

摘要： Vaccine formulation comprising EHV-1 gene 71 dysfunctional mutant and uses thereof.

公开(公告)号：EP2383343A2

公开(公告)日：2011-11-02

申请号：EP11153574.6

申请日：2005-03-03

申请人： The Research Foundation for Microbial Diseases of Osaka University

发明人： Nagaike, Kazuhiro ,  Mori, Yasuko ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Kouichi

IPC分类号： C12N15/38 ,  A61K39/25 ,  A61P31/22 ,  C12N5/10 ,  C12N7/00 ,  C07K14/04 ,  C12N7/04

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16761 ,  C12N2800/50 ,  C12N2820/55

摘要： A recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing recombinant varicella-zoster virus; a vector containing a genomic gene of varicella-zoster virus and BAC vector sequence; cells containing the above vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; and a nucleic acid cassette containing the BAC vector sequence. For these, there is provided a process for producing recombinant varicella-zoster virus, comprising use of the BAC vector sequence.

摘要翻译： 重组水痘带状疱疹病毒; 其制造方法; 含有重组水痘带状疱疹病毒的药物组合物; 含有水痘带状疱疹病毒和BAC载体序列的基因组基因的载体; 含有上述载体的细胞; 能够与水痘带状疱疹病毒基因组同源重组的片段; 和含有BAC载体序列的核酸盒。 为此，提供了一种生产重组水痘带状疱疹病毒的方法，其包括使用BAC载体序列。

公开(公告)号：EP1155119A4

公开(公告)日：2003-01-02

申请号：EP00904385

申请日：2000-01-18

申请人： UNIV KANSAS STATE

发明人： CHOWDHURY SHAFIQUL I

IPC分类号： G01N33/53 ,  A61K39/245 ,  A61P31/16 ,  A61P31/22 ,  A61P37/04 ,  C07K14/03 ,  C12N7/01 ,  C12N7/04 ,  C12N15/09 ,  C12N15/869 ,  C12Q1/34 ,  G01N33/573 ,  A61K39/265 ,  C12N15/38 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/543 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16743 ,  C12N2710/16761