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公开(公告)号：EP4251209A1
公开(公告)日：2023-10-04
申请号：EP21827768.9
申请日：2021-11-23
发明人： CHEN, Zhuoliang , D'ALESSIO, Joseph, Anthony , MCNEILL, Eric , NAKAJIMA, Katsumasa , NEWCOMBE, Richard, Vaughan , PALERMO, Mark, G. , YU, Bing , ZHANG, Qiang , COLLAND, Frederic , DAVIDSON, James, Edward Paul , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MURRAY, James, Brooke , NOVAK, Tibor , STARCK, Jérôme , BURGER, Matthew, T.
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公开(公告)号：EP3972651A2
公开(公告)日：2022-03-30
申请号：EP20733328.7
申请日：2020-05-19
发明人： BURGER, Matthew, T. , CHANRION, Maia , COLLAND, Frédéric , CSEKEI, Marton , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , HENLIN, Jean-Michel , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MCNEILL, Eric , PALERMO, Mark, G. , ROCCHETTI, Francesca , STARCK, Jérôme , YU, Bing , ZHANG, Qiang , PROSZENYÁK, Ágnes , SIPOS, Szabolcs , CHEN, Zhuoliang , NAKAJIMA, Katsumasa , D'ALESSIO, Joseph, Anthony
IPC分类号： A61K47/68
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公开(公告)号：EP3972649A2
公开(公告)日：2022-03-30
申请号：EP20730922.0
申请日：2020-05-19
发明人： BURGER, Matthew, T. , CHANRION, Maia , COLLAND, Frédéric , CSEKEI, Marton , DELACOUR, Lea , DESOS, Patrice , GENESTE, Olivier , HENLIN, Jean-Michel , KOSTOVA, Vesela , KOTSCHY, Andras , MARAGNO, Ana, Leticia , MCNEILL, Eric , PALERMO, Mark, G. , ROCCHETTI, Francesca , STARCK, Jérôme , YU, Bing , ZHANG, Qiang , PROSZENYÁK, Ágnes , SIPOS, Szabolcs , CHEN, Zhuoliang , NAKAJIMA, Katsumasa , D'ALESSIO, Joseph, Anthony , BLANKENSHIP, John, William
IPC分类号： A61K47/68
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公开(公告)号：EP4251208A1
公开(公告)日：2023-10-04
申请号：EP21827762.2
申请日：2021-11-23
发明人： CHEN, Zhuoliang , D'ALESSIO, Joseph, Anthony , KLINTER, Claudia, Judith , MCNEILL, Eric , MUNDT, Cornelia, Anne , NAKAJIMA, Katsumasa , NEWCOMBE, Richard, Vaughan , PALERMO, Mark, G. , SCHWEIGHOFFER, Tamas , YU, Bing , WINKELBACH, Katharina , ZHANG, Qiang , BRESSON, Laura , COLLAND, Frédéric , MARAGNO, Ana, Leticia , ROCCHETTI, Francesca , BURGER, Matthew, T.
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公开(公告)号：EP3310771A1
公开(公告)日：2018-04-25
申请号：EP16731665.2
申请日：2016-06-15
申请人： Novartis AG
发明人： CHEN, Zhuoliang , FORTANET, Jorge Garcia , LAMARCHE, Matthew J. , SENDZIK, Martin , TAMEZ, JR., Victoriano , YU, Bing
IPC分类号： C07D401/04 , C07D401/14 , C07D491/107 , A61K31/537 , A61K31/513 , A61K31/4545 , A61P35/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P25/28
摘要： The present invention relates to compounds of formula I. The compounds are inhibitors of the Src Homolgy-2 phosphatase (SHP2) and thus useful in the treatment of Noonan Syndrome, Leopard Syndrome and cancer.
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6.发明公开N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 审中-公开的N- AZASPIROCYCLOALKANSUBSTITUIERTE N-杂环芳基化合物和组合物用于抑制SHP2的活度
公开(公告)号：EP3094628A1
公开(公告)日：2016-11-23
申请号：EP15703321.8
申请日：2015-01-16
申请人： Novartis AG
发明人： CHEN, Christine Hiu-tung , CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KARKI, Rajesh , KATO, Mitsunori , LAMARCHE, Matthew J. , PEREZ, Lawrence Blas , SMITH, Troy Douglas , WILLIAMS, Sarah , GIRALDES, John William , TOURE, Bakary-barry , SENDZIK, Martin
IPC分类号： C07D241/18 , C07D241/20 , A61K31/495 , A61P35/04
CPC分类号： C07D498/10 , C07B2200/07 , C07D241/18 , C07D241/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/10 , C07D491/107 , C07D495/10
摘要： in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
摘要翻译： 其中P，Q，Y1，Y2，R1，R 2A，2B，3A，3B，4A，4B，5A，R 5B，R 7和R 8在发明概述中所定义; 能够抑制SHP2的活性。 本发明进一步提供了一种用于本发明的化合物的制备方法，药物制剂，其包括测试的化合物并使用化合物的方法和在与SHP2的异常活性相关的疾病或病症的管理审查的组合物。
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公开(公告)号：EP2318389A1
公开(公告)日：2011-05-11
申请号：EP09780696.2
申请日：2009-07-16
申请人： Novartis AG
发明人： HE, Feng , PEUKERT, Stefan , MILLER-MOSLIN, Karen , YUSUFF, Naeem , CHEN, Zhuoliang , LAGU, Bharat
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D471/04 , A61K31/501 , A61K31/506 , A61P35/00
CPC分类号： C07D237/20 , A61K31/4427 , A61K31/4523 , A61K31/501 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D471/04
摘要： The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.
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公开(公告)号：EP2102229A1
公开(公告)日：2009-09-23
申请号：EP07844058.3
申请日：2007-10-10
申请人： NOVARTIS AG
发明人： CHAREST, Mark G. , CHEN, Christine Hiu-tung , CHEN, Ming , CHEN, Zhuoliang , DAI, Miao , HE, Feng , LEI, Huangshu , STRAUB, Christopher , WANG, Run-Ming David , ZAWEL, Leigh
CPC分类号： C07K5/06191
摘要： The present invention relates to novel IAP inhibitor compounds of: Formula (I).
摘要翻译： 本发明涉及新的IAP抑制剂化合物：式（I）。
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公开(公告)号：EP2086938A1
公开(公告)日：2009-08-12
申请号：EP07862645.4
申请日：2007-12-07
申请人： NOVARTIS AG
IPC分类号： C07D213/75 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/06 , A61K31/44 , A61P35/00
CPC分类号： C07D405/12 , C07D213/75 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/06
摘要： The present disclosure relates to XIAP inhibitor compound of the formula I: [Chemical formula should be inserted here as it appears on Abstract in paper form] Formula I
摘要翻译： 本公开内容涉及式I的XIAP抑制剂化合物：[化学式在此以摘要呈现在纸上时插入此处]式I
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公开(公告)号：EP3310779B1
公开(公告)日：2019-05-08
申请号：EP16731341.0
申请日：2016-06-15
申请人： Novartis AG
发明人： BAGDANOFF, Jeffrey T. , CHEN, Zhuoliang , DORE, Michael , FORTANET, Jorge Garcia , KATO, Misunori , LAMARCHE, Matthew J. , SARVER, Patrick James , SHULTZ, Michael , SMITH, Troy Douglas , WILLIAMS, Sarah
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00 , A61P9/00 , A61P19/00 , A61P21/00 , A61P25/28
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