-
公开(公告)号：EP1791815A2
公开(公告)日：2007-06-06
申请号：EP05701246.0
申请日：2005-01-28
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D207/12 , A61K31/4015 , A61P11/06
CPC分类号： C07D207/12 , C07D211/26
摘要： Compounds of formula (I) in free or salt form, wherein T, X, Y, U, R1, R2, m, n and p have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
-
公开(公告)号：EP1778628A1
公开(公告)日：2007-05-02
申请号：EP05770044.5
申请日：2005-08-09
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： C07C275/28 , C07C275/26 , C07C275/34 , C07D261/06 , A61K31/17 , A61P37/08
CPC分类号： C07C275/30 , C07C275/24 , C07C275/28 , C07C275/34 , C07D261/14
摘要： Compounds of formula (I) in free or salt form, wherein T, X, R1, R2, Ra, R3, R4, R5 and U have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, particularly an inflammatory or allergic condition such as an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离形式或盐形式的式（I）化合物，其中T，X，R1，R2，Ra，R3，R4，R5和U具有说明书中所示的含义，可用于治疗由CCR-3介导的病症 特别是炎性或过敏性病症，例如炎性或阻塞性气道疾病。 还描述了含有用于制备该化合物的化合物和方法的药物组合物。
-
公开(公告)号：EP2231280B1
公开(公告)日：2016-08-10
申请号：EP08860731.2
申请日：2008-12-09
申请人： Novartis AG
发明人： BHALAY, Gurdip , BUDD, Emma , BLOOMFIELD, Graham Charles , COLLINGWOOD, Stephen Paul , DUNSTAN, Andrew , EDWARDS, Lee , GEDECK, Peter , HOWSHAM, Catherine , HUNT, Peter , HUNT, Thomas Anthony , OAKLEY, Paul , SMITH, Nichola
IPC分类号： C07D471/10 , A61K31/497 , C07D403/12 , C07D471/04 , C07D487/10 , C07D519/00 , C07D471/20 , C07D473/34 , C07D487/04
CPC分类号： C07D519/00 , A61K31/497 , C07D403/12 , C07D471/04 , C07D471/10 , C07D471/20 , C07D473/34 , C07D487/04 , C07D487/10
-
公开(公告)号：EP2231280A2
公开(公告)日：2010-09-29
申请号：EP08860731.2
申请日：2008-12-09
申请人： Novartis AG
发明人： BHALAY, Gurdip , BUDD, Emma , BLOOMFIELD, Graham Charles , COLLINGWOOD, Stephen Paul , DUNSTAN, Andrew , EDWARDS, Lee , GEDECK, Peter , HOWSHAM, Catherine , HUNT, Peter , HUNT, Thomas Anthony , OAKLEY, Paul , SMITH, Nichola
IPC分类号： A61P11/00 , A61K31/4965 , C07D241/26 , C07D403/12 , C07D487/10 , C07D471/04 , C07D473/34 , C07D487/04
CPC分类号： C07D519/00 , A61K31/497 , C07D403/12 , C07D471/04 , C07D471/10 , C07D471/20 , C07D473/34 , C07D487/04 , C07D487/10
摘要： A compound of Formula (I) in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. Diseases named to respond to epithelian sodium channel (ENaC) blockade are inflammatory or allergic conditions selected from: cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis.
-
5.发明公开PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS 有权炎症或过敏的治疗痛苦SUITABLE嘧啶衍生物
公开(公告)号：EP2173722A2
公开(公告)日：2010-04-14
申请号：EP08775347.1
申请日：2008-07-24
申请人： Novartis AG
IPC分类号： C07D239/34 , C07D239/42 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D419/12 , A61K31/506 , A61P35/00
CPC分类号： C07D239/34 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar', A and B are defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
-
6.发明授权PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS 有权炎症或过敏的治疗痛苦SUITABLE嘧啶衍生物
公开(公告)号：EP2173722B1
公开(公告)日：2012-08-29
申请号：EP08775347.1
申请日：2008-07-24
申请人： Novartis AG
发明人： BRUCE, Ian , DUNSTAN, Andrew , HUNT, Thomas Anthony , HOWSHAM, Catherine , HORVATH, Amarylla , ULLRICH, Thomas
IPC分类号： C07D239/34 , C07D239/42 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D419/12 , A61K31/506 , A61P35/00
CPC分类号： C07D239/34 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12
-
公开(公告)号：EP1791815B1
公开(公告)日：2010-11-17
申请号：EP05701246.0
申请日：2005-01-28
申请人： Novartis AG
IPC分类号： C07D207/12 , A61K31/4015 , A61P11/06
CPC分类号： C07D207/12 , C07D211/26
摘要： Compounds of formula (I) in free or salt form, wherein T, X, Y, U, R1, R2, m, n and p have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.015 秒)
