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6 条记录 (耗时 0.011 秒)

    VLA-4 INTEGRIN ANTAGONISTS
    6.
    发明公开
    VLA-4 INTEGRIN ANTAGONISTS 审中-公开
    VLA-4整联蛋白拮抗剂

    公开(公告)号：EP1235793A2

    公开(公告)日：2002-09-04

    申请号：EP00990650.4

    申请日：2000-12-05

    申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

    发明人： WATTANASIN, Sompong ,  WEIDMANN, Beat

    IPC分类号： C07C275/38 ,  C07D295/13 ,  A61K31/5375 ,  A61K31/17 ,  A61P27/02

    CPC分类号： C07D295/185 ,  A61K31/5375 ,  C07C275/42 ,  C07C279/28 ,  C07D295/13

    摘要： Compounds of formula (I) wherein Ar is carbocyclic or heterocyclic aryl, or biaryl; Q is O, S or N-C N; X is arylene; V is NH, O, NHOH, CH2 or a direct bond; W is NH, O, NHOH, CH2 or a direct bond; Alk is C2-C7-alkylene or C2-C7-alkylene interrupted by O, S, SO, SO2 or NR3; Y is amino, acylamino, mono- or di- (lower alkyl, aryl or aralkyl)-amino, pyrrolidino, perhydroazepino or a group of the formula (II) in which M1 is N; and M2 is CH2, O, NR3, S, SO or SO2; R1, R2 and R3 are independently hydrogen, lower alkyl, lower alkenyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or aryl-lower alkenyl; Z is lower alkylene or lower alkylene substituted by one or more of lower alkyl, lower alkenyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or aryl-lower alkenyl; or Z is lower alkylene interrupted by O, S, SO, SO2 or NR3; pharmaceutically acceptable esters and amides thereof; and pharmaceutically acceptable salts thereof, which are useful as VLA-4 integrin antagonists.