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公开(公告)号：EP1332137A2
公开(公告)日：2003-08-06
申请号：EP01988712.4
申请日：2001-10-26
发明人： BUCHDUNGER, Elisabeth , CAPDEVILLE, Renaud , DEMETRI, George, Daniel , DIMITRIJEVIC, Sasa , DRUKER, Brian, J. , FLETCHER, Jonathan, A. , JOENSUU, Heikki,c/oHelsinki Univ Central Hospital , SILBERMAN, Sandra, Leta , TUVESON, David , HEINRICH, Michael, C.
IPC分类号： C07D241/00
CPC分类号： C07D401/04 , A61K31/506
摘要： 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula (I) or a pharmaceutically acceptable salt thereof can be used in the treatment of gastrointestinal stromal tumours.
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公开(公告)号：EP1332137B1
公开(公告)日：2006-03-29
申请号：EP01988712.4
申请日：2001-10-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BUCHDUNGER, Elisabeth , CAPDEVILLE, Renaud , DEMETRI, George, Daniel , DIMITRIJEVIC, Sasa , DRUKER, Brian, J. , FLETCHER, Jonathan, A. , JOENSUU, Heikki, c/oHelsinki Univ Central Hospital , SILBERMAN, Sandra, Leta , TUVESON, David , HEINRICH, Michael, C.
IPC分类号： A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , A61K31/506
摘要： 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula (I) or a pharmaceutically acceptable salt thereof can be used in the treatment of gastrointestinal stromal tumours.
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3.发明公开
公开(公告)号：EP1667719A1
公开(公告)日：2006-06-14
申请号：EP04765359.7
申请日：2004-09-17
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： A61K45/06 , A61P35/00 , A61K31/497 , A61K31/553
CPC分类号： A61K45/06 , A61K31/497 , A61K31/553 , A61K2300/00
摘要： The present invention relates to the use of a combination comprising (a) imatinib or a pharmaceutically acceptable salt thereof and midostaurin or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of gastrointestinal stromal tumors, e.g. imatinib-resistant gastro-intestinal stromal tumors.
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4.发明授权
公开(公告)号：EP1667719B1
公开(公告)日：2010-11-24
申请号：EP04765359.7
申请日：2004-09-17
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K45/06 , A61P35/00 , A61K31/497 , A61K31/553
CPC分类号： A61K45/06 , A61K31/497 , A61K31/553 , A61K2300/00
摘要： The present invention relates to the use of a combination comprising (a) imatinib or a pharmaceutically acceptable salt thereof and midostaurin or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of gastrointestinal stromal tumors, e.g. imatinib-resistant gastro-intestinal stromal tumors.
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