公开(公告)号：EP1615898B1

公开(公告)日：2014-10-29

申请号：EP04726485.8

申请日：2004-04-08

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLLBUCK, Birgit ,  DENHOLM, Alastair Novartis Horsham Research Ctre. ,  EDER, Jörg ,  HERSPERGER, René ,  JANSER, Philipp ,  RÉVÉSZ, Lászlo ,  SCHLAPBACH, Achim ,  WÄLCHLI, Rudolf

IPC分类号： C07D239/42 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D409/04 ,  C07D413/10 ,  A61K31/506 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D239/42 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/10

公开(公告)号：EP1615898A1

公开(公告)日：2006-01-18

申请号：EP04726485.8

申请日：2004-04-08

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BOLLBUCK, Birgit ,  DENHOLM, Alastair Novartis Horsham Research Ctre. ,  EDER, Jörg ,  HERSPERGER, René ,  JANSER, Philipp ,  R V SZ, Lászlo ,  SCHLAPBACH, Achim ,  WÄLCHLI, Rudolf

IPC分类号： C07D239/42 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D409/04 ,  C07D413/10 ,  A61K31/506 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P19/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D239/42 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/10

摘要： A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables haue the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent.