公开(公告)号：EP0994880B1

公开(公告)日：2005-01-19

申请号：EP98936392.4

申请日：1998-06-26

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： DOSENBACH, Cornelia ,  GRASSBERGER, Maximilian ,  HARTMANN, Otto ,  HORVATH, Amarylla ,  MUTZ, Jean-Paul ,  PENN, Gerhard ,  PFEFFER, Sabine ,  WIECKHUSEN, Dierk

IPC分类号： C07D498/18

CPC分类号： C07D498/18 ,  C30B7/00

摘要： 33-Epichloro-33-desoxyascomycin of formula (I) and various tautomeric or solvated forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula (I), or compound of formula (I) in other than Form A, or compound of formula (I) in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively. Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.

公开(公告)号：EP0994880A1

公开(公告)日：2000-04-26

申请号：EP98936392.4

申请日：1998-06-26

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： DOSENBACH, Cornelia ,  GRASSBERGER, Maximilian ,  HARTMANN, Otto ,  HORVATH, Amarylla ,  MUTZ, Jean-Paul ,  PENN, Gerhard ,  PFEFFER, Sabine ,  WIECKHUSEN, Dierk

IPC分类号： C07D498/18

CPC分类号： C07D498/18 ,  C30B7/00

摘要： 33-Epichloro-33-desoxyascomycin of formula (I) and various tautomeric or solvated forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula (I), or compound of formula (I) in other than Form A, or compound of formula (I) in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively. Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.