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公开(公告)号：EP0994880A1
公开(公告)日：2000-04-26
申请号：EP98936392.4
申请日：1998-06-26
发明人： DOSENBACH, Cornelia , GRASSBERGER, Maximilian , HARTMANN, Otto , HORVATH, Amarylla , MUTZ, Jean-Paul , PENN, Gerhard , PFEFFER, Sabine , WIECKHUSEN, Dierk
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C30B7/00
摘要： 33-Epichloro-33-desoxyascomycin of formula (I) and various tautomeric or solvated forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula (I), or compound of formula (I) in other than Form A, or compound of formula (I) in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively. Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.
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公开(公告)号：EP3317248A1
公开(公告)日：2018-05-09
申请号：EP15744416.7
申请日：2015-07-02
申请人： Novartis AG
发明人： HOOK, David , HU, Bin , KLEINBECK, Florian Karl , MEIER, Ulrich , MUELLER, Sibylle , MUTZ, Jean-Paul , SCHLOMACH, Jan , SUTTON, Paul Allen , WAYKOLE, Liladhar Murlidhar , WIETFELD, Bernhard
IPC分类号： C07C229/34 , A61K31/221 , A61P9/00
摘要： The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.
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公开(公告)号：EP3782978A1
公开(公告)日：2021-02-24
申请号：EP20196280.0
申请日：2015-07-02
申请人： Novartis AG
发明人： HOOK, David , HU, Bin , KLEINBECK, Florian Karl , MEIER, Ulrich , MUELLER, Sibylle , MUTZ, Jean-Paul , SCHLOMACH, Jan , SUTTON, Paul Allen , WAYKOLE, Liladhar Murlidhar , WIETFELD, Bernhard
IPC分类号： C07C229/34 , A61K31/221 , A61P9/00 , A61P25/00
摘要： The invention relates to polymorphic forms of the calcium salt of N -(3-carboxyl-1-oxopropyl)-(4 S )-( p -phenylphenylmethyl)-4-amino-(2 R )-methyl butanoic acid ethyl ester. The calcium salt of N -(3-carboxyl-1-oxopropyl)-(4 S )-( p -phenylphenylmethyl)-4-amino-(2 R )-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.
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公开(公告)号：EP3317248B1
公开(公告)日：2020-09-16
申请号：EP15744416.7
申请日：2015-07-02
申请人： Novartis AG
发明人： HOOK, David , HU, Bin , KLEINBECK, Florian Karl , MEIER, Ulrich , MUELLER, Sibylle , MUTZ, Jean-Paul , SCHLOMACH, Jan , SUTTON, Paul Allen , WAYKOLE, Liladhar Murlidhar , WIETFELD, Bernhard
IPC分类号： C07C229/34 , A61K31/221 , A61P9/00
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公开(公告)号：EP0994880B1
公开(公告)日：2005-01-19
申请号：EP98936392.4
申请日：1998-06-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： DOSENBACH, Cornelia , GRASSBERGER, Maximilian , HARTMANN, Otto , HORVATH, Amarylla , MUTZ, Jean-Paul , PENN, Gerhard , PFEFFER, Sabine , WIECKHUSEN, Dierk
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C30B7/00
摘要： 33-Epichloro-33-desoxyascomycin of formula (I) and various tautomeric or solvated forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula (I), or compound of formula (I) in other than Form A, or compound of formula (I) in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively. Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.
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