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公开(公告)号：EP1539263B1
公开(公告)日：2007-09-12
申请号：EP03747998.7
申请日：2003-09-10
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
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公开(公告)号：EP1252222B1
公开(公告)日：2005-11-09
申请号：EP01919255.8
申请日：2001-02-02
申请人： Novartis AG , Novartis Pharma GmbH
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公开(公告)号：EP1648534A1
公开(公告)日：2006-04-26
申请号：EP04741077.4
申请日：2004-07-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： QIU, Yongxing , LALLY, John, Martin
CPC分类号： G02B1/043 , A01N59/16 , A61L12/088 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/442 , A61L2300/624 , B29D11/00038 , B82Y30/00
摘要： The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extendedwear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
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公开(公告)号：EP1539263A1
公开(公告)日：2005-06-15
申请号：EP03747998.7
申请日：2003-09-10
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
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公开(公告)号：EP1575633A2
公开(公告)日：2005-09-21
申请号：EP03813580.2
申请日：2003-12-18
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.
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公开(公告)号：EP1465679A1
公开(公告)日：2004-10-13
申请号：EP03729232.3
申请日：2003-01-08
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L2400/10 , Y10T428/31667 , Y10T428/31884 , Y10T428/31891 , Y10T428/31935 , Y10T428/31971
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a lubricious coating including a capping layer of polyvinylpyrrolidone and/or at least one layer of a lubricious coating material and one layer of a polyionic material having charges opposite of the charges of the lubricious coating material. The lubricious coating on the medical device of the invention has increased lubricity, preferably characterized by an averaged CoF of about 3.0 or less, increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, and increased bacterial adhesion resistance, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides provides a method for making a medical device, preferably a contact lens, having a lubricious coating thereon.
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公开(公告)号：EP1429818A2
公开(公告)日：2004-06-23
申请号：EP02750993.4
申请日：2002-05-29
申请人： Novartis AG , Novartis Pharma GmbH
发明人： LALLY, John, Martin , WINTERTON, Lynn, Cook , MORRIS, Carol, Ann , QIU, Yongxing , CARNEY, Fiona, Patricia , KOTOV, Nicola
IPC分类号： A61L31/00
CPC分类号： A61L27/34 , A61L27/306 , A61L31/088 , A61L31/10 , G02B1/043
摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.
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公开(公告)号：EP1402288A1
公开(公告)日：2004-03-31
申请号：EP02738126.8
申请日：2002-05-29
申请人： Novartis AG , Novartis Pharma GmbH
发明人： AGUADO, Celeste , LALLY, John, Martin , NICOLSON, Paul, Clement , QIU, Yongxing , SCHREMMER, Jacalyn, Mary , WINTERTON, Lynn, Cook
CPC分类号： G02B1/043 , A61L27/18 , A61L27/26 , A61L27/34 , A61L2430/16 , Y10T428/31663 , C08L51/085
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
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公开(公告)号：EP1540381B1
公开(公告)日：2007-01-31
申请号：EP03757817.6
申请日：2003-09-10
申请人： Novartis AG , Novartis Pharma GmbH
摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.
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10.发明授权METHOD FOR MAKING MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON 有权用于生产VONMEDIZINPRODUKTEN与抗菌涂料
公开(公告)号：EP1575632B1
公开(公告)日：2006-04-26
申请号：EP03813579.4
申请日：2003-12-18
发明人： RUBNER, Michael, F. , YANG, Sung, Yun , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having -COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the -COO- groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
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