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    ERGOLINE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR LIGANDS
    7.
    发明公开
    ERGOLINE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR LIGANDS 审中-公开
    麦角灵衍生物和它们作为趋化因子受体配体的用途

    公开(公告)号：EP1893611A1

    公开(公告)日：2008-03-05

    申请号：EP06753946.0

    申请日：2006-05-29

    申请人： Novartis AG

    发明人： BAENTELI, Rolf ,  GLICKMAN, Fraser ,  KOVARIK, Jiri ,  LEWIS, Ian ,  STREIFF, Markus ,  THOMA, Gebhard ,  ZERWES, Hans-Günter

    IPC分类号： C07D457/06 ,  C07D457/08 ,  A61K31/48

    CPC分类号： C07D457/06 ,  C07D457/08

    摘要： Disclosed are ergoline derivatives, Formula (I), wherein either each of R1 and R2, independently, is H; optionally R10 and/or R11-substituted-phenyl or - phenyl-C1-4alkyl; optionally R10 and/or R11-substituted-heteroaryl or -heteroaryl-C1-4alkyl; optionally R10 and/or R11-substituted heteroaryl N-oxide; optionally R10-substituted C1-C8 alkyl; optionally R10-substituted C2-C8 alkenyl, optionally R10-substituted C2-C8 alkynyl; optionally R10-substituted C3-C8 cycloalkyl, or optionally R10-substituted C4-C8 cycloalkenyl; or R1 and R2 form together with the nitrogen atom to which they are attached an optionally R10-substituted 3-8 membered ring containing in addition to the nitrogen atom up to 2 heteroatoms selected independently from N, O and S; R3 is H; OR1; CH2R1R2; (CH2)1-2NR1R2; CH2-CH2-OR1; CH2-CO-NR1R2; or CO-CH2R1R2; R4 is F; CI; Br; I; OR1; NR1R2 or has one of the significances given for R1; and R5 has one of the significances given for R1, in free form or in salt form for preventing or treating disorders or diseases mediated by interactions between chemokine receptors and their ligands.