公开(公告)号：EP0836605B1

公开(公告)日：2002-02-06

申请号：EP96923893.0

申请日：1996-06-24

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： TRAXLER, Peter ,  BOLD, Guido ,  BRILL, Wolfgang, Karl-Diether ,  FREI, Jörg

IPC分类号： C07D487/04 ,  C07D471/14 ,  A61K31/505 ,  C07D207/34 ,  C07D471/04

CPC分类号： C07D471/14 ,  C07D207/34 ,  C07D487/04

公开(公告)号：EP1153024A1

公开(公告)日：2001-11-14

申请号：EP00916840.2

申请日：2000-02-16

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： IMBACH, Patricia ,  CAPRARO, Hans-Georg ,  ZIMMERMANN, Jürg ,  CARAVATTI, Giorgio ,  FURET, Pascal ,  BRILL, Wolfgang, Karl-Diether

IPC分类号： C07D473/16 ,  C07D473/40 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/16 ,  C07D473/40

摘要： 2-Amino-6-anilino-purine derivatives of formula (I) in which R1 is -S(O)k-NR6R7 or-N(aryl lower alkyl) carbamoyl or -NH-S(O)i-R8 or -NH-C(O)-R9; 9 is 1-5; These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and protein tyrosine kinase pp60c-src and can be used for treatment of hyperproliferative diseases, for example tumour diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60c-src, in particular osteoporosis.

公开(公告)号：EP1153024B1

公开(公告)日：2004-04-28

申请号：EP00916840.2

申请日：2000-02-16

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： IMBACH, Patricia ,  CAPRARO, Hans-Georg ,  ZIMMERMANN, Jürg ,  CARAVATTI, Giorgio ,  FURET, Pascal ,  BRILL, Wolfgang, Karl-Diether

IPC分类号： C07D473/16 ,  C07D473/40 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/16 ,  C07D473/40

摘要： 2-Amino-6-anilino-purine derivatives of formula (I) in which R1 is -S(O)k-NR6R7 or-N(aryl lower alkyl) carbamoyl or -NH-S(O)i-R8 or -NH-C(O)-R9; 9 is 1-5; These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and protein tyrosine kinase pp60c-src and can be used for treatment of hyperproliferative diseases, for example tumour diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60c-src, in particular osteoporosis.

公开(公告)号：EP0836605A1

公开(公告)日：1998-04-22

申请号：EP96923893.0

申请日：1996-06-24

申请人： Novartis AG

发明人： TRAXLER, Peter ,  BOLD, Guido ,  BRILL, Wolfgang, Karl-Diether ,  FREI, Jörg

IPC分类号： A61K31 ,  A61P35 ,  A61P43 ,  C07D207 ,  C07D471 ,  C07D487

CPC分类号： C07D471/14 ,  C07D207/34 ,  C07D487/04

摘要： Described are 7H-pyrrolo[2,3-d]pyrimidine derivatives of formula (I) wherein the symbols are as defined in claim 1. Those compounds inhibit tyrosine protein kinase and can be used in the treatment of hyperproliferative diseases, for example tumour diseases.