公开(公告)号：EP1049663A1

公开(公告)日：2000-11-08

申请号：EP99907393.5

申请日：1999-01-20

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： HALL, Roger, Graham ,  STEIGER, Arthur ,  HÜTER, Ottmar, Franz ,  PASCUAL, Alfons ,  KRIZ, Miroslav ,  TRAH, Stephan

IPC分类号： C07C255/66 ,  C07C317/32 ,  C07C323/48 ,  C07D307/32 ,  C07D333/12 ,  C07D213/53 ,  A01N37/34 ,  A01N41/10 ,  A01N43/08 ,  A01N43/10

CPC分类号： C07C255/66 ,  A01N37/34 ,  A01N41/08 ,  A01N43/08 ,  A01N43/10 ,  A01N43/40 ,  A01N43/80 ,  A01N43/82 ,  A01N47/28 ,  A01N47/34 ,  C07C311/16 ,  C07C317/34 ,  C07C317/44 ,  C07C323/36 ,  C07C323/62 ,  C07C2601/02 ,  C07D213/53 ,  C07D271/08 ,  C07D275/03 ,  C07D307/74 ,  C07D333/44

摘要： Compounds of formula (I), wherein: A1 and A2 each represent independently of one other an aryl or a heteroaryl radical; and A1 where appropriate is substituted with substituent (R3a)n1 and A2 where appropriate with substituent (R3b)n2; n1 and n2 are independently of one another 0, 1, 2, 3 or 4; and either R3a and R3b independently of one another are for example halogen, C1-C6alkyl, C2-C4alkinyl, halogen-C1-C6alkyl, halogen-C2-C4alkinyl, C1-C6alkoxy, halogen-C1-C6alkoxy, C2-C6alkenyloxy, C2-C6alkinyloxy or halogen-C2-C6alkenyloxy; and R2 is R2a; R2a is for example -C1-C6alkyl-NR11R12, -COC9-C20alkyl, -C1-C6alkyl-O-C1-C6alkyl-O-C1-C6alkyl or -CH2O(C=O)C1-C6alkyl; or, at least one of the radicals R3a or R3b is -CR5=CR5R14, -NR11R12, -C(=O)CN, -C(=O)C(=O)O-C1-C6alkyl, -CR7=NOR10, or a five or six-membered heteroaryl ring bonded by a carbon atom; R2 is R2a or R2b, wherein R2a is as defined hereinbefore; and R2b is for example hydrogen, -OH, C1-C6alkyl or C1-C6alkoxy; R14 is for example hydrogen, halogen, C1-C6alkyl or halogen-C1-C6alkyl; X is O or S; p is 0, 1 or 2; R5 is independently H or C1-C8alkyl; R6 is for example independently H, C1-C8alkyl or C3-C6cycloalkyl; R7 is for example H, C1-C8alkyl, C2-C8alkenyl or halogen-C1-C8alkyl; R8 is for example C1-C8alkyl, C1-C8alkenyl or halogen-C1-C8alkyl; R9 is C1-C6alkyl, halogen-C1-C4alkyl or aryl; R10 is H, C1-C6alkyl, C3-C6cycloalkyl, phenyl or benzyl; R11 and R12 for example are independently of one another H, C1-C6alkyl or phenyl; and where applicable the possible E/Z isomers, E/Z isomer mixtures and/or tautomers thereof, in free form or in agrochemically acceptable form, can be used as agrochemical active ingredients and may be prepared in a known manner.

摘要翻译： 式（I）化合物，其中：A1和A2各自独立地表示芳基或杂芳基; 适当时，取代基（R3a）n1和A2与取代基（R3b）n2适当地取代; n1和n2彼此独立地为0,1,2,3或4; R 3a和R 3b彼此独立地是例如卤素，C 1 -C 6烷基，C 2 -C 4炔基，卤素-C 1 -C 6烷基，卤素-C 2 -C 4炔基，C 1 -C 6烷氧基，卤素-C 1 -C 6烷氧基 ，C 2 -C 6烯氧基，C 2 -C 6烷氧基或卤素-C 2 -C 6烯氧基; R2为R2a; R2a是例如-C1-C6烷基-NR11R12，-COC9-C20烷基，-C1-C6烷基-O-C1-C6烷基-O-C1-C6烷基或-CH2O（C = O）C1-C6烷基; 基团R 3a或R 3b中的至少一个为-CR 5 = CR 5 R 14，-NR 11 R 12，-C（= O）CN，-C（= O）C（= O）O-C 1〜 C6烷基，-CR7 = NOR10，或被碳原子键合的五元或六元杂芳环; R2是R2a或R2b，其中R2a如上所定义; 并且R 2b是例如氢，-OH，C 1 -C 6烷基或C 1 -C 6烷氧基; R 14是例如氢，卤素，C 1 -C 6烷基或卤素-C 1 -C 6烷基; X为O或S; p为0,1或2; R5独立地为H或C1-C8烷基; R6例如独立地为H，C1-C8烷基或C3-C6环烷基; R 7是例如H，C 1 -C 8烷基，C 2 -C 8烯基或卤素-C 1 -C 8烷基; R8是例如C1-C8烷基，C1-C8链烯基或卤素-C1-C8烷基; R 9为C 1 -C 6烷基，卤素-C 1 -C 4烷基或芳基; R 10是H，C 1 -C 6烷基，C 3 -C 6环烷基，苯基或苄基; R 11和R 12例如彼此独立地为H，C 1 -C 6烷基或苯基; 并且如果适用，游离形式或农业化学上可接受的形式的可能的E / Z异构体，E / Z异构体混合物和/或互变异构体可用作农业化学活性成分，并且可以以已知方式制备。

公开(公告)号：EP0984923A1

公开(公告)日：2000-03-15

申请号：EP98932081.7

申请日：1998-05-25

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： TRAH, Stephan ,  SZCZEPANSKI, Henry ,  HÜTER, Ottmar, Franz ,  HALL, Roger, Graham ,  FAROOQ, Saleem ,  PASCUAL, Alfons

IPC分类号： C07C251/60 ,  C07D261/08 ,  C07D261/20 ,  A01N37/50

CPC分类号： C07F9/4021 ,  C07C251/60 ,  C07D261/08 ,  C07D261/20 ,  C07F9/3229 ,  C07F9/5325

摘要： Compounds of formula (I), wherein either X is CH or N, Y is OR1 and Z is O, or X is N, Y is NHR8 and Z is O, S or S (=O); R1, R2 and R3 are as defined according to the specification; m is 0, 1 or 2; R5 is, for example, halogen, C1-C6alkyl, halo-C1-C6alkyl or C3-C6cycloalkyl; n is 0, 1, 2, 3 or 4; R9 is methyl, fluoromethyl or difluoromethyl; A and R7 are as defined according to the specification; D is O, S, -S(=O) or S(=O)2; G is C1-C8alkylene; T-R6 is R6, -C(=N-O-A1-R77)-R6; -SiR14(R15)-R6; -C(=O)-R6; -C(R16)=C(R17)-R6, -C≡C-R6 or -D-R6; R6 is C1-C4alkyl or unsubstituted or substituted aryl or heteroaryl; A1 and R77 are as defined above for A and R7; L is U-R18, P(O)vR11R12, P(S)wR11R12 or N(aryl)R13; v and w are 0 or 1; U-R18 is -C(=O)-C(=O)-R18; -C(OH)-C(OH)-R18; -C(=N-O-A1-R7)-R18; (i) or (ii); a is 0 or 1; b is 0 or 1; R11, R12 and R13 are, for example, C1-C6alkyl, halo-C1-C6alkyl or C3-C6cycloalkyl; R14 and R15 are each independently of the other C1-C4alkyl; R16 and R17 are each independently of the other hydrogen, C1-C4alkyl or halogen and R18 is R5; and, where applicable, their possible E/Z isomers, mixtures of E/Z isomers and/or tautomers, in each case in free form or in salt form, a method of controlling pests, a process for the preparation of those compounds and their use are described.

摘要翻译： 其中X是CH或N，Y是OR1且Z是O，或X是N，Y是NHR8且Z是O，S或S（= O）的式（I）化合物。 R1，R2和R3如根据说明书所定义; m是0,1或2; R5是例如卤素，C1-C6烷基，卤代-C1-C6烷基或C3-C6环烷基; n是0,1,2,3或4; R9是甲基，氟甲基或二氟甲基; A和R7如根据说明书所定义; D是O，S，-S（= O）或S（= O）2; G是C1-C8亚烷基; T-R6是R6，-C（= N-O-A1-R77）-R6; -SiR14（R15）-R 6; -C（= O）-R 6; -C（R 16）= C（R 17）-R 6，-C≡C-R 6或-D-R 6; R6是C1-C4烷基或未取代或取代的芳基或杂芳基; A1和R77如以上A和R7所定义; L是U-R18，P（O）vR11R12，P（S）wR11R12或N（芳基）R13; v和w是0或1; U-R18是-C（= O）-C（= O）-R18; -C（OH）-C（OH）-R18; -C（= N-O-A1-R7）-R18; （i）或（ii）; a是0或1; b是0或1; 例如，R 11，R 12和R 13是C 1 -C 6烷基，卤代-C 1 -C 6烷基或C 3 -C 6环烷基; R14和R15各自独立于另一个C1-C4烷基; R 16和R 17各自独立地为氢，C 1 -C 4烷基或卤素且R 18为R 5; 并且在适用的情况下，它们可能的E / Z异构体，E / Z异构体和/或互变异构体的混合物，各自以游离形式或盐形式存在，控制害虫的方法，制备这些化合物及其 描述使用。

公开(公告)号：EP0946531A1

公开(公告)日：1999-10-06

申请号：EP97953841.0

申请日：1997-12-17

申请人： Novartis AG

发明人： PITTERNA, Thomas ,  SZCZEPANSKI, Henry ,  MAIENFISCH, Peter ,  HÜTER, Ottmar, Franz ,  RAPOLD, Thomas ,  SENN, Marcel ,  GÖBEL, Thomas ,  O'SULLIVAN, Anthony, Cornelius ,  SEIFERT, Gottfried

IPC分类号： C07D277 ,  C07D417

CPC分类号： C07D277/32 ,  C07D277/16 ,  C07D277/36 ,  C07D417/06

摘要： The invention relates to a process for the preparation of a compound of formula (I), wherein Q, Y, Z, R1, R2, R3, R4 and R5 are as defined in the specification, which comprises a) reacting a compound of formula (II), with a halogenating agent to form a compound of formula (III), or b) converting a compound of formula (II) by means of a halogenating agent into a compound of formula (IV); optionally c) converting the compound of formula (IV) into a compound of formula (III); d) converting a compound of formula (III) by means of a compound of formula (V) into a compound of formula (VI); or e) converting a compound (IV) by means of a compound (V) into a compound (VI); and f) converting a compound (VI) by means of a chlorinating agent into a compound (I); a compound (IV); to a process for the preparation of a compound (III) and to a process for the preparation of a compound (IV).

摘要翻译： 本发明涉及制备式（I）化合物的方法，其中Q，Y，Z，R 1，R 2，R 3，R 4和R 5如说明书中所定义，其包括a）使式 （II）化合物与卤化剂反应以形成式（III）化合物，或者b）借助卤化剂将式（II）化合物转化为式（IV）化合物; 任选c）将式（IV）化合物转化成式（III）化合物; d）通过式（V）化合物将式（III）化合物转化为式（VI）化合物; 或者e）通过化合物（V）将化合物（IV）转化为化合物（VI）; 和f）通过氯化剂将化合物（VI）转化为化合物（I）; 化合物（IV）; 涉及制备化合物（III）的方法和制备化合物（IV）的方法。

公开(公告)号：EP0946532A1

公开(公告)日：1999-10-06

申请号：EP97954817.0

申请日：1997-12-17

申请人： Novartis AG

发明人： PITTERNA, Thomas ,  SZCZEPANSKI, Henry ,  MAIENFISCH, Peter ,  HÜTER, Ottmar, Franz ,  RAPOLD, Thomas ,  SENN, Marcel ,  GÖBEL, Thomas ,  O'SULLIVAN, Anthony, Cornelius

IPC分类号： C07D277

CPC分类号： C07D277/32 ,  C07D277/16 ,  C07D277/36 ,  C07D277/70 ,  C07D277/74

摘要： Described is a process for the preparation of a compound of formula (I) wherein R is unsubstituted or substituted C1-C12alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, aryl or heteroaryl, or -SR1; R1 is unsubstituted or substituted C1-C12alkyl, C2-C4alkenyl, C2-C4alkynyl, cycloalkyl, aryl or heteroaryl; and X is a leaving group; which comprises: a) reacting a compound of formula (II) wherein R is as defined for formula (I), with a water-removing reagent; or b) for the preparation of a compound of formula (I) wherein X is halogen or a sulfonate, reacting a compound of the formula (III) wherein R is as defined for formula (I), with a halogenating or a sulfonylating agent; or c) for the preparation of a compound of formula (I) wherein X is halogen, reacting a compound of formula (IV) wherein R is as defined for formula (I); and wherein R2 and R3 are for example H, C1-C6alkyl, C3-C6cycloalkyl, phenyl or benzyl; with a compound of the formula halogen-C(=O)-O-C1-C8alkyl, halogen-C(=O)-O-aryl or halogen-C(=O)-O-benzyl. Intermediates for the preparation of the synthesis of compounds (II) to (IV) and method of the preparation thereof.

公开(公告)号：EP0912499A1

公开(公告)日：1999-05-06

申请号：EP97925980.0

申请日：1997-06-04

申请人： Novartis AG

发明人： SZCZEPANSKI, Henry ,  ZELLER, Martin ,  HÜTER, Ottmar, Franz

IPC分类号： A01N37 ,  A01N43 ,  C07C251 ,  C07D211 ,  C07D213 ,  C07D233 ,  C07D261 ,  C07D295

CPC分类号： C07D213/53 ,  A01N37/36 ,  A01N37/42 ,  A01N37/50 ,  A01N43/40 ,  A01N43/50 ,  A01N43/80 ,  C07C251/60 ,  C07C2601/16 ,  C07D211/76 ,  C07D233/86 ,  C07D261/08 ,  C07D295/155

摘要： Pesticidally active compounds of formula (I) wherein: X is CH or N; Y is O, S, S=O or NR5; Z is OR2, SR2 or N(R3)R4; n is 0, 1, 2, 3, 4 or 5; or Y and Z together form a 5- to 7-membered ring containing 2 or 3 hetero atoms O and/or N that is unsubstituted or mono- or poly-substituted by C1-C4alkyl, halo-C1-C4alkyl, halogen, =O or by cyclopropyl; W is an aldimino or ketimino group; R1 is cyclopropyl, C1-C6alkyl or halo-C1-C6alkyl; R2 and R3 are each independently of the other C1-C6alkyl or halo-C1-C6alkyl; R4 and R5 are each independently of the other hydrogen, C1-C6alkyl or C1-C6alkoxy; R8 and R9 are each independently of the other hydrogen or C1-C3alkyl; or R8 and R9 together are C2-C6alkenyl or C3-C6cycloalkyl; R21 and R22 are each independently of the other hydrogen, halogen, C1-C8alkyl, C1-C8alkoxy or C1-C8alkylthio; and R23, R24, R25 and R26 are each independently of the others hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy. The compounds may be used in the control of pests, especially as fungicides, acaricides and insecticides in plant protection.

摘要翻译： 式（I）的杀虫活性化合物，其中：X是CH或N; Y是O，S，S = O或NR 5; Z是OR2，SR2或N（R3）R4; n是0,1,2,3,4或5; 或Y和Z一起形成含有2或3个未被取代或被C 1 -C 4烷基，卤代-C 1 -C 4烷基，卤素，= O单取代或多取代的杂原子O和/或N的5-至7-元环 或通过环丙基; W是醛亚胺基或酮亚胺基; R 1是环丙基，C 1 -C 6烷基或卤代-C 1 -C 6烷基; R2和R3各自独立地为另一个C1-C6烷基或卤代C1-C6烷基; R4和R5各自独立地为氢，C1-C6烷基或C1-C6烷氧基; R 8和R 9各自独立地为氢或C 1 -C 3烷基; 或者R 8和R 9一起为C 2 -C 6烯基或C 3 -C 6环烷基; R 21和R 22各自独立地为氢，卤素，C 1 -C 8烷基，C 1 -C 8烷氧基或C 1 -C 8烷硫基; 和R 23，R 24，R 25和R 26各自独立地为氢，卤素，C 1 -C 8烷基或C 1 -C 8烷氧基。 这些化合物可用于防治害虫，特别是用作植物保护中的杀真菌剂，杀螨剂和杀虫剂。

公开(公告)号：EP0907634A1

公开(公告)日：1999-04-14

申请号：EP97927184.0

申请日：1997-06-16

申请人： Novartis AG

发明人： SZCZEPANSKI, Henry ,  ZELLER, Martin ,  HÜTER, Ottmar, Franz

IPC分类号： A01N37 ,  A01N43 ,  C07C69 ,  C07C251 ,  C07C255 ,  C07C323 ,  C07D213 ,  C07D239 ,  C07D241 ,  C07D261 ,  C07D263 ,  C07D277 ,  C07D317 ,  C07D333

CPC分类号： C07D213/30 ,  A01N37/38 ,  A01N37/50 ,  A01N43/40 ,  A01N43/80 ,  C07C69/736 ,  C07C251/42 ,  C07C251/54 ,  C07C255/62 ,  C07C323/60 ,  C07C2601/10 ,  C07D213/61 ,  C07D213/69 ,  C07D239/26 ,  C07D241/12 ,  C07D261/08 ,  C07D263/32 ,  C07D277/24 ,  C07D317/22 ,  C07D333/16

摘要： Compounds of formula (I) in which where X is CH or N; Y is O; S, S=O or NR5; Z is OR2, SR2, N(R3)R4; or Y and Z together form 5- to 7-membered ring which contains, 2 or 3 hetero atoms O and/or N and which is unsubstituted or substituted by C1-C4 alkyl, halo-C1-C4alkyl, halogen, =O or cyclopropyl; V is a direct bond or C1-C6alkylene, which is unsubstituted or substituted by C1-C3alkyl, C2-C3alkylidene or C3-C6cycloalkylidene; U is O, S, NR7, SO or SO2; W is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; R1 is cyclopropyl; C1-C6alkyl or halo-C1-C6alkyl; R2 and R3 independently of one another are C1-C6alkyl or halo-C1-C6alkyl; R4 and R5 independently of one another are hydrogen, C1-C6alkyl or C1-C6alkoxy; R7 is hydrogen, C1-C6alkyl, benzyl, C1-C6alkylcarbonyl, halo-C1-C6alkylcarbonyl, halo-C2-C6alkenylcarbonyl; R21 and R22 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy or C1-C8alkylthio; R23, R24, R25, R26 independently of one another are hydrogen, halogen, C1-C8alkyl or C1-C8alkoxy; are pesticidally active. They can be used for pest control, in particular as fungicides, acaricides and insecticides in crop protection.

公开(公告)号：EP0873326A1

公开(公告)日：1998-10-28

申请号：EP96939236.0

申请日：1996-12-02

申请人： Novartis AG

发明人： SZCZEPANSKI, Henry ,  GÖBEL, Thomas ,  HÜTER, Ottmar, Franz ,  O'SULLLIVAN, Anthony Cornelius, ,  SENN, Marcel ,  RAPOLD, Thomas ,  MAIENFISCH, Peter ,  PITTERNA, Thomas

IPC分类号： C07D ,  C07D277 ,  C07D417

CPC分类号： C07D277/32 ,  C07D277/36 ,  C07D417/06

摘要： The invention relates to a process for preparing a compound of formula (I), in which X is CH or N, Y is NO2 or CN, Z is CHR3, O, NR3 or S, R1 and R2 are either each, independently of the other, hydrogen or unsubstituted or R4-substituted alkyl or together a two- or three-membered alkylene bridge or a two- or three-membered alkylene bridge in which one member is replaced by a hetero member selected from the group, consisting of NR5, O and S, R3 is H or unsubstituted or R4-substituted alkyl, R4 is an unsubstituted or substituted aryl or heteroaryl group, and R5 is H or alkyl, which comprises a) reacting a compound of formula (II) with a chlorinating agent or b1) initially reacting a compound of formula (IV) with a compound of formula (V) and b2) further reacting the compound of formula (II) obtainable thereby, with or without intermediate isolation, with a chlorinating agent, to intermediates used in this process, to the use of these intermediates and to a process for the preparation of these intermediates.

摘要翻译： 本发明涉及制备式（I）化合物的方法，其中X是CH或N，Y是NO 2或CN，Z是CHR 3，O，NR 3或S，R 1和R 2各自独立地是 其它的氢或未被取代的或被R 4取代的烷基或一起形成二或三元亚烷基桥或二或三元亚烷基桥，其中一个成员被选自NR 5， O和S，R 3是H或未取代的或R 4取代的烷基，R 4是未取代或取代的芳基或杂芳基，且R 5是H或烷基，其包含a）使式（II）的化合物与氯化剂反应或 b1）首先使式（IV）化合物与式（V）化合物和b2）反应，并进一步使可由此得到的式（II）化合物与中间体分离或与中间体分离与氯化剂反应，得到中间体 过程，使用这些中间体以及制备过程 这些中间体。